M. Gorospe

Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis

This study identifies CD4+ cytotoxic T cells in the bone marrow that enhance granulopoiesis in aged mice, contributing to age-related diseases and showing that CCR5 inhibition can mitigate these effects.

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress

This study identifies the YAP-TEAD pathway as a target for senolytic therapy, showing that inhibiting it induces apoptosis in senescent cells by increasing ER stress.

Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

This study investigates BAFF's role in senescence by showing its cell-type-specific effects on SASP and growth arrest.

Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD+ depletion at tumor edge

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

Brain aging-dependent glioma traits reversible by NAD+/BDNF-mediated neuronal reactivation

This study shows that aging reduces neuronal signaling in gliomas, but NAD+ and BDNF can reverse these effects, improving outcomes in older mice.

Aging skeletal muscle proteomics finds changes in spliceosome, immune factors, proteostasis and mitochondria

This study identifies age-related changes in skeletal muscle proteomics, showing deficits in energy metabolism, increased inflammation, proteostasis, and alternative splicing.