Cell BiologybioRxivPreprint
Age-associated failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging
M. G. Perino, M. Calvo-Rubio Barrera, D. Riordon…·E. Lakatta
This study shows that aging impairs proteostatic mechanisms in mice with cardiac-specific over-expression of adenylyl cyclase VIII, leading to accelerated heart aging and cardiomyopathy.
DOI 10.1101/2023.08.13.553128