Author

A. Lyons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1

Frequent Co-Authors

M. T. Woodside· 2 shared N. R. Forde· 2 shared A. Al-Shaer· 1 shared A. B. Graf· 1 shared A. D. Chatziefthimiou· 1 shared A. Frolova· 1 shared A. M. Canas· 1 shared A. Narayan· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

M. T. Woodside

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Quantifying oligomer populations in real time during protein aggregation using single-molecule mass photometry

S. S. Paul, A. Lyons, R. Kirchner, M. T. Woodside

This study uses single-molecule mass photometry to track oligomer populations during protein aggregation, revealing kinetic models and rate constants for tau protein aggregation.

bioRxiv · Jun 15, 2022Biophysics

Structural dynamics of the SARS-CoV-2 frameshift-stimulatory pseudoknot reveal topologically distinct conformers

K. Neupane, M. Zhao, A. Lyons, S. Munshi, S. M. Ileperuma, D. B. Ritchie, N. Q. Hoffer, A. Narayan, M. T. Woodside

The paper investigates the structural dynamics of the SARS-CoV-2 frameshift-stimulatory pseudoknot under tension, revealing multiple conformers and their folding mechanisms.

bioRxiv · Dec 28, 2020Biophysics

Global Genetic Cartography of Urban Metagenomes andAnti-Microbial Resistance

D. C. Danko, D. Bezdan, E. Afshinnekoo, S. Ahsanuddin, C. Bhattacharya, D. J. Butler, K. R. Chng, D. Donnellan, J. Hecht, K. Jackson, K. Kuchin, M. Karasikov, A. Lyons, L. Mak, D. Meleshko, , Gr

The paper creates a global metagenomic atlas of urban microbial ecosystems, identifying novel species and geographic variation in antimicrobial resistance genes.

bioRxiv · Dec 2, 2020 · PreprintMicrobiology

Sequence-dependent mechanics of collagen reflect its structural and functional organization

A. Al-Shaer, A. Lyons, Y. Ishikawa, B. G. Hudson, S. Boudko, N. R. Forde

This study uses AFM to analyze how sequence variations in collagen IV and III affect their local flexibility, revealing that helix interruptions significantly influence mechanical properties.

bioRxiv · Sep 27, 2020Biophysics

Environmentally controlled curvature of single collagen proteins

N. Rezaei, A. Lyons, N. R. Forde

This study investigates collagen flexibility using AFM and a new algorithm, finding that collagen's conformation is modulated by salt and pH, not flexibility, and behaves as a curved worm-like chain.

bioRxiv · May 4, 2018Biophysics