Author

Y. Ishikawa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 2 Bioengineering· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

A. Al-Shaer· 1 shared A. B. Hamacher· 1 shared A. Hori· 1 shared A. Kaneko· 1 shared A. Lyons· 1 shared A. M. Salo· 1 shared B. G. Hudson· 1 shared C. C. dela Sena· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

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1 shared paperBiophysics

A. Al-Shaer

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Investigating EMT-mediated resistance to EGFR tyrosine kinase inhibitors in NSCLC using innovative organoid models

N. Kobayashi, S. Katakura, N. Fukuda, S. Teranishi, S. Kubo, C. Kamimaki, H. Matsumoto, K. Somekawa, A. Kaneko, Y. Ishikawa, K. Okudela, K. Sekine, T. Kaneko

This study investigates EMT-mediated resistance to EGFR TKIs in NSCLC using organoid models, finding links between EMT markers and resistance, and suggesting potential therapeutic strategies.

bioRxiv · Feb 8, 2024 · PreprintCancer Biology

A monochromatically excitable green-red dual-fluorophore fusion incorporating a new large Stokes shift fluorescent protein

J. O. Ejike, M. Sadoine, Y. Shen, Y. Ishikawa, E. Sunal, S. Hänsch, A. B. Hamacher, W. B. Frommer, M. M. Wudick, R. E. Campbell, T. J. Kleist

The paper introduces a new fluorescent protein, LSSmApple, and uses it to create a genetically encoded calcium sensor for yeast imaging.

bioRxiv · Jul 16, 2023Bioengineering

Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis

L. Zhang, M. Tang, X. Tao, Q. Shao, V. Thomas, S. Shimizu, M. Kasano, Y. Ishikawa, T. Inukai, D. K. Nomura

This study identifies a covalent inhibitor EN25 that targets GCLM to inhibit glutathione synthesis in ARID1A-deficient cancer cells.

bioRxiv · May 18, 2023Biochemistry

Low-dose cytokine immunotherapy of solid cancers enabled by phagocytic-competent protein co-crystals

M. H. Jones, N. E. Quispe Calla, R. Smith, C. Talbot Cooper, S. Rudge, H. Kusano, T. Shiomi, Y. Ishikawa, H. Zeng, J. D. Best

This study demonstrates that PODS-IL-2, a phagocytic-competent protein co-crystal, can deliver low-dose IL-2 effectively for treating melanoma and renal cell carcinoma with improved tolerability.

bioRxiv · Apr 6, 2023 · PreprintCancer Biology

Sequence-dependent mechanics of collagen reflect its structural and functional organization

A. Al-Shaer, A. Lyons, Y. Ishikawa, B. G. Hudson, S. Boudko, N. R. Forde

This study uses AFM to analyze how sequence variations in collagen IV and III affect their local flexibility, revealing that helix interruptions significantly influence mechanical properties.

bioRxiv · Sep 27, 2020Biophysics

Re-evaluation of lysyl hydroxylation in the collagen triple helix: lysyl hydroxylase 1 and prolyl 3-hydroxylase 3 have site-differential and collagen type-dependent roles in lysine hydroxylation.

Y. Ishikawa, Y. Taga, K. Zientek, N. Mizuno, A. M. Salo, O. Semenova, S. Tufa, D. R. Keene, P. Holden, K. Mizuno, J. Myllyharju, H. P. Bächinger

This study investigates the roles of P3H3 and LH1 in lysyl hydroxylation in collagen, finding distinct site-specific and collagen-type-dependent functions.

bioRxiv · Dec 16, 2019Biochemistry

Membrane Protrusion Formation Mediated by Rho/ROCK Signalling and Modulation of Chloride Flux

A. Hori, K. NIshide, Y. Yasukuni, K. Haga, W. Kakuta, Y. Ishikawa, M. Hayes, S.-i. Ohnuma, H. Kiyonari, K. Kimura, T. Kondo, N. Sasai

This study shows Prom1 triggers membrane protrusions via Rho/ROCK signaling and chloride efflux, independent of actin/tubulin polymerization.

bioRxiv · Apr 5, 2019 · PreprintCell Biology

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

M. M. Szewczyk, Y. Ishikawa, S. Organ, N. Sakai, F. Li, S. Ackloo, M. S. Eram, D. Dilworth, H. Fukushi, R. Harding, C. C. dela Sena, T. Sugo, K. Hayashi, D. Macleod, C. Zepeda, , D. Barsyte-Lovejoy

This study identifies a PRMT7 inhibitor and shows its effect on arginine methylation of stress proteins, linking PRMT7 to cellular stress response.

bioRxiv · Mar 15, 2019Biochemistry