Polyamine Depletion by D, L-alpha-difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis
R. Offenbacher, K. Jackson, M. Hayashi, J. Zhang, D. Peng, Y. Tan, T. M. Stewart, P. Ciero, J. R. Foley, R. A. Casero, P. Cahan, D. M. Loeb
This study shows DFMO inhibits Ewing sarcoma metastasis by inducing ferroptosis through polyamine depletion.
bioRxiv · Jun 14, 2024Cancer Biology