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A. M. Amen

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:wet-lab / biochemical assay· 1

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A. M. McKinney· 1 shared A. Mancini· 1 shared C. Fellmann· 1 shared G. J. Knott· 1 shared J. A. Doudna· 1 shared J. E. Park· 1 shared J. F. Costello· 1 shared K. M. Soczek· 1 shared

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1 shared paperCancer Biology

A. M. McKinney

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1 paper

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Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewedMar 23, 2021

Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage

A. M. Amen, C. Fellmann, K. M. Soczek…·J. F. Costello

This study shows that reducing GABPB1L in TERT-mutant glioblastomas, combined with chemotherapy, reduces tumor growth by impairing DNA damage response.

DOI 10.1073/pnas.2008772118

humanbulk RNA-seq

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