Cancer BiologybioRxiv
Differentiated neuroblastoma cells remain epigenetically poised for de-differentiation to an immature state
R. Guyer, N. Picard, J. L. Mueller…·A. M. Goldstein
This study shows neuroblastoma cells can switch between a neuronal gene expression state and a de-differentiated state, with CD49b marking proliferative immature cells and CD49b-negative cells capable of generating tumors.