BiophysicsbioRxiv
Probing remdesivir nucleotide analogue insertion to SARS-CoV-2 RNA dependent RNA polymerase in viral replication
M. E. Romero, C. Long, D. La Rocco…·J. Yu
This study computationally examines how remdesivir nucleotide analogue binds and inserts into SARS-CoV-2 RdRp, showing it has a lower energy barrier than ATP insertion.
DOI 10.1039/d1me00088h