C. Long

Cross-reactivity of rPvs48/45, a recombinant Plasmodium vivax protein, with sera from Plasmodium falciparum endemic areas of Africa

This paper evaluates the cross-reactivity of a recombinant Plasmodium vivax protein with sera from Plasmodium falciparum-exposed individuals and demonstrates its transmission-blocking activity against P. falciparum.

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived sSCF

The paper identifies resting NK cells that promote colon cancer liver metastasis by enhancing tumor-derived sSCF through cell-to-cell interactions.

Mesenchymal stem cells of the bone marrow raise infectivity of Plasmodium falciparum gametocytes

This study shows that bone marrow mesenchymal stem cells increase the infectivity of Plasmodium falciparum gametocytes, enhancing mosquito infection rates.

Antibody gene features associated with binding and functional activity in vaccine-derived human mAbs targeting malaria parasites

This study identifies antibody gene features linked to binding and functional activity in vaccine-derived human mAbs against malaria parasites, showing adjuvant effects on clonotype diversity.

An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs.

The paper compares mesenchymal-like gene expression programs in neuroblastoma preclinical models and patient tumors using single-cell RNA-seq and identifies chemotherapy-induced changes in PDX and GEMM.

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

Peripheral extracellular vesicle-derived miR-150-3p exacerbates acute kidney injury following acute pancreatitis by promoting ferroptosis through FTH1 signaling

This study identifies miR-150-3p in extracellular vesicles as a mediator of ferroptosis in acute kidney injury following acute pancreatitis.

Phage DNA polymerase prevents deleterious on-target damage and enhances precise CRISPR/Cas9 editing

This study identifies T4 DNA polymerase as a tool to enhance CRISPR/Cas9 editing precision by reducing on-target deletions and translocations while increasing insertion accuracy.

Hemisynthetic derivatives of the natural alkaloid trilobine are fast-acting antimalarial compounds with sustained activity in multi-drug resistant P. falciparum isolates

Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies

This study determines the structure of Pfs48/45, a malaria vaccine candidate, and identifies antibody binding sites that block parasite transmission.

High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signaling.

This paper shows high-dose vitamin D reduces myostatin and increases leptin production and sensitivity, directing excess calories to muscle and growth rather than fat.

Glycerol-driven Denitratation: Process Kinetics, Microbial Ecology, and Operational Controls

This study optimizes glycerol-driven denitratation for nitrogen removal, showing higher nitrate reduction rates and identifying operational controls and microbial ecology factors.

Probing remdesivir nucleotide analogue insertion to SARS-CoV-2 RNA dependent RNA polymerase in viral replication

This study computationally examines how remdesivir nucleotide analogue binds and inserts into SARS-CoV-2 RdRp, showing it has a lower energy barrier than ATP insertion.

Allosteric regulation in CRISPR/Cas1-Cas2 protospacer acquisition mediated by DNA in association with Cas2

This study shows that PAMc recognition and cleavage in one Cas1-Cas2 site allosterically regulate non-PAMc association in the other site, mediated by Cas2 and DNA.

Increased light availability enhances tolerance against ocean acidification stress in Halimeda opuntia

Increased light availability enhances stress resistance in Halimeda opuntia by the accumulation of soluble organic molecules and enzyme-driven activities to alleviate ocean acidification stress.

Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria and produce parasite inhibitory IgM

The paper identifies Pf-specific IgM B cells in children, showing they expand during malaria and produce inhibitory IgM antibodies.

Iron-deficiency and estrogen are associated with ischemic stroke by up-regulating transferrin to induce hypercoagulability

The paper shows that iron-deficiency and estrogen increase transferrin, leading to hypercoagulability and worsened ischemic stroke.

Microbial biogeography and ecology of the mouth and implications for periodontal diseases

This paper explores microbial biogeography in the human mouth, linking spatial patterns to periodontal diseases and proposing methods to test hypotheses about subgingival microbiota variation.