Author
A. M. Patel
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2019-2021 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 21 mutual co-author links5 papers
Recent·Most cited
Viperin inhibits cholesterol biosynthesis and interacts with enzymes in the cholesterol biosynthetic pathway
T. J. Grunkemeyer, S. Ghosh, A. M. Patel, K. Sajja, J. Windak, V. Basrur, Y. S. Kim, A. I. Nesvizhskii, R. T. Kennedy, E. N. G. Marsh
This study shows viperin reduces cholesterol levels by inhibiting key enzymes in the biosynthetic pathway, though the exact mechanism remains unclear.
bioRxiv · Feb 19, 2021 · PreprintBiochemistry
The human liver microenvironment shapes the homing and function of CD4+ T-cell populations
B. G. Wiggins, L. J. Pallett, X. Li, S. P. Davies, O. E. Amin, U. S. Gill, A. M. Patel, K. Aliazis, Y. S. Liu, G. M. Reynolds, G. Hirschfield, P. F. Kennedy, Y. Huang, M. M. Maini, Z. Stamataki
This study identifies two distinct CD4+ T cell subsets in the human liver, characterized by CD69 expression levels, with different functional profiles and microenvironmental requirements.
bioRxiv · Aug 3, 2020Immunology
The Interaction of Viperin with Hepatitis C Virus Non-Structural Protein 5A Inhibits the Catalytic Activity of Viperin
S. Ghosh, A. M. Patel, T. J. Grunkemeyer, A. B. Dumbrepatil, K. Zagalia, R. T. Kennedy, E. N. G. Marsh
This study shows viperin interacts with NS5A and VAP-33, reducing NS5A levels and viperin activity, suggesting NS5A evolved to inhibit ddhCTP synthesis.
bioRxiv · Oct 30, 2019 · PreprintBiochemistry
Interactions between Viperin, IRAK1 and TRAF6 couple innate immune signaling to antiviral ribonucleotide synthesis
A. B. Dumbrepatil, S. Ghosh, A. M. Patel, P. A. Malec, K. Zegalia, J. D. Hoff, R. T. Kennedy, E. N. G. Marsh
This study shows that Viperin, IRAK1, and TRAF6 interact to link innate immune signaling with antiviral ddhCTP synthesis through ubiquitination and enzymatic activation.
bioRxiv · Jan 11, 2019 · PreprintBiochemistry