V. Basrur

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

This study identifies LONP1's role in mitochondrial protein folding and shows its impact on beta cell survival and hyperglycemia in type 2 diabetes.

Identification of LMAN1 and SURF4 dependent secretory cargoes

The paper identifies secretory cargoes dependent on LMAN1 and SURF4 using CRISPR knockout and mass spectrometry in HuH7 cells, revealing distinct cargo repertoires and complex recognition mechanisms.

Autoinhibited kinesin-1 adopts a hierarchical folding pattern

This study determines the structure of autoinhibited kinesin-1 using XL-MS, EM, and AlphaFold, showing how light chains stabilize the inhibited state and how activation requires disrupting multiple domain interactions.

Spatial control of Keratin 8 phosphorylation by Aurora B facilitates cytokinesis in cancer cells of epithelial origin

The paper shows Aurora B phosphorylates Keratin 8 at the cleavage furrow, facilitating its disassembly during cytokinesis in epithelial cancer cells.

Identification of secreted proteins by comparison of protein abundance in conditioned media and cell lysates.

The paper identifies secreted proteins by comparing their abundance in conditioned media and cell lysates, finding proteins enriched in media as potential secreted candidates.

Multi-omic Characterization of Pancreatic Cancer-Associated Macrophage Polarization Reveals Deregulated Metabolic Programs Driven by the GMCSF-PI3K Pathway

This study identifies metabolic markers and pathways in pancreatic tumor-associated macrophages using multi-omic analysis and in vitro models.

Viperin inhibits cholesterol biosynthesis and interacts with enzymes in the cholesterol biosynthetic pathway

This study shows viperin reduces cholesterol levels by inhibiting key enzymes in the biosynthetic pathway, though the exact mechanism remains unclear.

Selenium-dependent metabolic reprogramming during inflammation and resolution

This study shows selenium enhances metabolic reprogramming in macrophages during inflammation resolution by modulating key metabolic pathways.

Mutant EGFR is a preferred SMURF2 substrate of ubiquitination: role in enhanced receptor stability and TKI sensitivity

This paper identifies SMURF2-mediated ubiquitination of EGFR mutants as a mechanism enhancing receptor stability and TKI sensitivity.

Differential glycosylation of alpha-1-acid glycoprotein (AGP-1) contributes to its functional diversity.

This study shows that differential glycosylation of AGP-1 leads to distinct functional effects on neutrophils and platelets during inflammation.

Tyrosine phosphorylation of ACLY regulates lipid metabolism and oncogenesis in ALK positive Anaplastic Large Cell Lymphoma

This study identifies tyrosine phosphorylation of ACLY at Y682 as a regulatory mechanism linked to lipid metabolism and oncogenesis in ALK-positive ALCL.

Acute phase protein, α-1-acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses.

This study shows AGP-1 enhances TLR-2 but not TLR-4 mediated inflammatory responses in vitro and in vivo, suggesting a role in sepsis pathobiology.