Author

A. Marchetto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Pathology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 10 Assay:bulk RNA-seq· 9 Approach:statistical model· 9 Research Focus:differential expression· 7 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

J. Li· 10 shared J. Musa· 10 shared M. F. Orth· 10 shared S. Ohmura· 10 shared T. Kirchner· 10 shared G. Sannino· 8 shared J. S. Gerke· 8 shared T. G. P. Grunewald· 8 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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10 shared papersCancer Biology

J. Li

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10 papers

Recent·Most cited

Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma

S. Ohmura, A. Marchetto, M. F. Orth, J. Li, S. Jabar, A. Ranft, E. Vinca, K. Ceranski, M. J. Carreno-Gonzalez, L. Romero-Perez, F. S. Wehweck, J. Musa, F. Bestvater, M. M. L. Knott, T. L. B. Hoelting, , T. G. P. Grunewald

This study identifies RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma, showing its overexpression correlates with poor survival and that its inhibition reduces tumor growth and overcomes chemoresistance.

bioRxiv · Mar 4, 2021Cancer Biology

Systems biology analysis identifies TCF7L1 as a key regulator of metastasis in Ewing sarcoma

F. Cidre-Aranaz, J. Li, T. L. B. Hoelting, M. F. Orth, R. Imle, S. Kutschmann, G. Ammirati, K. Ceranski, M. J. Carreno-Gonzalez, M. Kasan, A. Marchetto, C. M. Funk, F. Bestvater, S. Bersini, C. Arrigoni, , T. G. P. Gruenewald

bioRxiv · Feb 25, 2021 · PreprintCancer Biology

Cooperation of dominant oncogenes with regulatory germline variants shapes clinical outcomes in childhood cancer

J. Musa, F. Cidre-Aranaz, M.-M. Aynaud, M. F. Orth, O. Mirabeau, M. Varon, S. Grossetete, D. Surdez, S. Ohmura, J. S. Gerke, A. Marchetto, M. Dallmayer, M. C. Baldauf, M. Gartlgruber, F. Westermann, , T. G. P. Grunewald

This study shows how a dominant oncogene and regulatory germline variants together influence tumor growth, survival, and drug response in Ewing sarcoma.

Nature Communications · Sep 11, 2019Peer-reviewedCancer Biology

Oncogenic hijacking of a developmental transcription factor evokes therapeutic vulnerability for ROS-induction in Ewing sarcoma

A. Marchetto, S. Ohmura, M. F. Orth, J. Li, F. S. Wehweck, M. M. L. Knott, S. Stein, D. Saucier, C. Arrigoni, J. S. Gerke, M. C. Baldauf, J. Musa, M. Dallmayer, T. L. B. Hoelting, M. Moretti, , T. G. P. Grunewald

The paper identifies SOX6 as a therapeutic target in Ewing sarcoma by showing its role in elevating ROS levels, making the disease vulnerable to ROS-inducing drugs.

bioRxiv · Mar 14, 2019Cancer Biology

Biomarker-based outcome prediction in prostate adenocarcinoma depends on the TMPRSS2-ERG status

J. S. Gerke, M. F. Orth, Y. Tolkach, L. Romero-Perez, F. S. Wehweck, S. Stein, J. Musa, M. M. L. Knott, T. L. B. Hoelting, J. Li, G. Sannino, A. Marchetto, S. Ohmura, F. Cidre-Aranaz, M. Mueller-Nurasyid, , T. G. P. Grunewald

This study identifies subtype-specific prognostic biomarkers in prostate adenocarcinoma, showing that their prognostic value depends on TMPRSS2-ERG fusion status.

bioRxiv · Feb 10, 2019Cancer Biology

SOX2 expression identifies Ewing sarcoma patients with high risk for tumor relapse and poor survival

G. Sannino, A. Marchetto, A. Ranft, S. Jabar, C. Zacherl, R. Alba-Rubio, S. Stein, F. S. Wehweck, M. M. Kiran, T. L. B. Hoelting, J. Musa, L. Romero-Perez, F. Cidre-Aranaz, M. M. L. Knott, J. Li, , T. G. P. Grunewald

bioRxiv · Dec 17, 2018Pathology

Targeting the CALCB/RAMP1-axis inhibits growth of Ewing sarcoma

M. Dallmayer, J. Li, S. Ohmura, R. Alba-Rubio, M. C. Baldauf, T. L. B. Hoelting, J. Musa, M. M. L. Knott, S. Stein, F. Cidre-Aranaz, F. S. Wehweck, L. Romero-Perez, J. S. Gerke, M. F. Orth, A. Marchetto, , T. G. P. Grunewald

This study identifies CALCB as a direct EWSR1-FLI1 target in Ewing sarcoma and shows that targeting the CALCB/RAMP1-axis inhibits tumor growth.

bioRxiv · Dec 8, 2018Cancer Biology

Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma

M. F. Orth, J. S. Gerke, T. Knosel, A. Altendorf-Hofmann, J. Musa, R. Alba Rubio, S. Stein, M. Dallmayer, M. C. Baldauf, A. Marchetto, G. Sannino, S. Ohmura, J. Li, M. Hakozaki, T. Kirchner, , T. G. P. Grunewald

This study identifies AMPD2 as a prognostic biomarker for undifferentiated pleomorphic sarcoma using transcriptome analysis, immunohistochemistry, and functional assays.

bioRxiv · Mar 31, 2018Pathology

Systematic identification of cancer-specific MHC-binding peptides with RAVEN

M. C. Baldauf, J. S. Gerke, A. Kirschner, F. Blaeschke, M. Effenberger, K. Schober, R. Alba Rubio, T. Kanaseki, M. M. Kiran, M. Dallmayer, J. Musa, N. Akpolat, A. N. Akatli, F. C. Rosman, O. Ozen, , T. G. Grunewald

The paper introduces RAVEN, a software tool that identifies cancer-specific genes encoding MHC-affine peptides from gene expression data, validated across 50 cancer types.

bioRxiv · Sep 24, 2017Immunology

Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets

M. C. Baldauf, M. F. Orth, M. Dallmayer, A. Marchetto, J. S. Gerke, R. Alba Rubio, M. M. Kiran, J. Musa, M. M. L. Knott, S. Ohmura, J. Li, N. Akpolat, A. N. Akatli, O. Ozen, U. Dirksen, , T. G. P. Grunewald

This study identifies ATP1A1, BCL11B, and GLG1 as specific immunohistochemical markers for Ewing sarcoma, offering high specificity for diagnosis.

bioRxiv · Jul 2, 2017Pathology