D. Surdez

Genomic and phenotypic stability of fusion-driven pediatric Ewing sarcoma cell lines

This study compares genomic and phenotypic stability of pediatric Ewing sarcoma cell lines to adult carcinoma cell lines over 12 months of culture.

Simple droplet microfluidics platform for drug screening on cancer spheroids

This paper presents a microfluidics platform for drug screening on cancer spheroids, reducing cell requirements and enabling sequential drug exposure.

COMBINATION THERAPIES TARGETING ALK-ABERRANT NEUROBLASTOMA IN PRECLINICAL MODELS.

This study evaluates lorlatinib, an ALK inhibitor, in combination with chemotherapy or idasanutlin in preclinical neuroblastoma models, finding synergy in models with high ALK expression.

Integrative genomics uncover mechanisms of renal medullary carcinoma transformation, microenvironment landscape and therapeutic vulnerabilities.

This study uses single-cell and multi-region sequencing to define RMC transformation, identify cell states, and uncover therapeutic vulnerabilities through transcriptional changes and microenvironment interactions.

VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis

This study identifies VGLL2-NCOA2 as an oncogene driving pediatric sarcomagenesis by reactivating developmental programs, with ARF6 overexpression as a potential therapeutic target.

Automated compound testing in zebrafish xenografts identifies combined MCL-1 and BCL-XL inhibition to be effective against Ewing sarcoma

Longitudinal high-resolution imaging through a flexible intravital imaging window

This study presents a versatile, fully flexible imaging window that acts as an implantable transparent second skin for small laboratory animal in vivo imaging.

Interplay between intrinsic reprogramming potential and microenvironment controls neuroblastoma cell plasticity and identity

This study shows that neuroblastoma cells can switch between noradrenergic and mesenchymal identities through epigenetic reprogramming, influenced by both intrinsic factors and the microenvironment.

Cooperation of dominant oncogenes with regulatory germline variants shapes clinical outcomes in childhood cancer

This study shows how a dominant oncogene and regulatory germline variants together influence tumor growth, survival, and drug response in Ewing sarcoma.

Transcriptional programs define intratumoral heterogeneity of Ewing sarcoma at single cell resolution

This study identifies transcriptional programs driving intratumoral heterogeneity in Ewing sarcoma using single-cell RNA-sequencing and chromatin analysis.