BiophysicsbioRxiv
The role of evolutionary selection in the dynamics of protein structure evolution
A. I. Gilson, A. Marshall-Christensen, J.-M. Choi, E. I. Shakhnovich
The paper shows that evolutionary selection for folding stability maintains protein structure despite sequence divergence, but allows rare structural innovations over longer timescales.
DOI 10.1016/j.bpj.2017.02.029