Author

A. Mir

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. J. Sontheimer· 2 shared A. J. Debacker· 1 shared A. Khvorova· 1 shared A. Wang· 1 shared C. Zheng· 1 shared D. Echeverria· 1 shared D. Rodgers· 1 shared E. Hudgens· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioengineering

E. J. Sontheimer

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Perfusable Apparatus For Thick-tissue Creation And Growth (patch) Of Cardiac Tissue

A. Mir, I. Pitaktong, J. Y. He, K. Nurminsky, T. Dunn, S. Koljaka, O. Dunn, S. Ran, D. Rodgers, A. Wang, H. Matsushita, N. Hibino, W. Shih

The paper develops a bioreactor system using 3D bioprinting and perfusion to create and maintain thick, viable cardiac tissue from iPSCs and fibroblasts.

bioRxiv · Jul 18, 2022 · PreprintBioengineering

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

P. Liu, S. Liang, C. Zheng, E. Mintzer, Y. G. Zhao, K. Ponnienselvan, A. Mir, E. J. Sontheimer, G. Gao, T. R. Flotte, S. Wolfe, W. Xue

This paper improves prime editors for genome editing in adult mice, enabling pathogenic mutation correction and cancer modeling.

Nature Communications · Apr 9, 2021Peer-reviewedBioengineering

Heavily and Fully Modified RNAs Guide Efficient SpyCas9-Mediated Genome Editing

A. Mir, J. F. Alterman, M. R. Hassler, A. J. Debacker, E. Hudgens, D. Echeverria, M. H. Brodsky, A. Khvorova, J. K. Watts, E. J. Sontheimer

This study identifies heavily and fully modified crRNA and tracrRNA that enhance Cas9-mediated genome editing efficiency and stability in human cells.

bioRxiv · Mar 28, 2018Biochemistry