Author

S. Wolfe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

P. Liu· 3 shared E. J. Sontheimer· 2 shared E. Mintzer· 2 shared J. Luban· 2 shared K. Luk· 2 shared A. Mir· 1 shared C. A. Schiffer· 1 shared C. H. O. Lam· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

P. Liu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing

T. C. Rodriguez, L. Yurkovetskiy, K. Nagalekshmi, C. H. O. Lam, E. Jazbec, S. A. Maitland, S. Wolfe, E. J. Sontheimer, J. Luban

The paper identifies PRC1.6 as a partner of the HUSH complex in promoter-specific provirus silencing through chromatin colocalization and functional assays.

bioRxiv · Jul 12, 2024 · PreprintMicrobiology

Direct delivery of stabilized Cas-embedded base editors achieves efficient and accurate editing of clinically relevant targets

J. M. Lee, J. Zeng, P. Liu, M. A. Nguyen, D. S. Loustaunau, D. Bauer, N. K. Yilmaz, S. Wolfe, C. A. Schiffer

This study develops stabilized Cas-embedded base editors (sCE_CBEs) that enable efficient and accurate C-to-T editing with minimal off-target effects in hematopoietic stem and progenitor cells.

bioRxiv · Feb 8, 2024 · PreprintBiochemistry

Global profiling of human blood ILC subtypes reveals that NK cells produce homeostatic cytokine amphiregulin and sheds light on HIV-1 pathogenesis

Y. Wang, L. Lifshitz, N. Silverstein, E. Mintzer, K. Luk, P. StLouis, M. Brehm, S. Wolfe, S. Deeks, J. Luban

This study identifies NK cell production of amphiregulin in human blood ILCs and links it to HIV-1 pathogenesis through cytokine signaling and immune cell dynamics.

bioRxiv · Apr 20, 2021 · PreprintImmunology

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

P. Liu, S. Liang, C. Zheng, E. Mintzer, Y. G. Zhao, K. Ponnienselvan, A. Mir, E. J. Sontheimer, G. Gao, T. R. Flotte, S. Wolfe, W. Xue

This paper improves prime editors for genome editing in adult mice, enabling pathogenic mutation correction and cancer modeling.

Nature Communications · Apr 9, 2021Peer-reviewedBioengineering

mtDNA replication in dysfunctional mitochondria promotes deleterious heteroplasmy via the UPRmt

Q. Yang, P. Liu, N. Anderson, T. Shpilka, Y. Du, N. Uma Naresh, K. Luk, J. Lavelle, R. Zeinert, P. Chien, S. Wolfe, C. Haynes

The paper shows ATFS-1 promotes {Delta}mtDNA replication by recruiting POLG, while LONP-1 inhibition increases wildtype mtDNA binding and improves heteroplasmy ratio and OXPHOS function.

bioRxiv · Sep 1, 2020 · PreprintCell Biology

SIR proteins create compact heterochromatin fibers

S. Swygert, S. Senapati, M. Bolukbasi, S. Wolfe, S. Lindsay, C. L. Peterson

This study reconstitutes SIR heterochromatin fibers in budding yeast and shows they are highly compact, requiring H4K16 and Sir3-Sir4 interactions.

bioRxiv · Jun 13, 2018Biochemistry