W. Xue

Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response

This study identifies how the coronavirus N protein disrupts nucleocytoplasmic trafficking and suppresses the innate immune response by promoting RACK1-PKC interaction and NUP62 phosphorylation.

Integrated Hfq-interacting RNAome and transcriptomic analysis reveals complex regulatory networks of nitrogen fixation in root-associated Pseudomonas stutzeri A1501

This study identifies Hfq-binding RNAs in Pseudomonas stutzeri A1501 using eCLIP-seq, revealing new regulatory targets involved in nitrogen fixation and other metabolic processes.

T492I mutation alters SARS-CoV-2 properties via modulating viral non-structural proteins

The paper investigates the T492I mutation in SARS-CoV-2 NSP4, showing it increases transmissibility, replication, and antibody evasion by enhancing NSP5 cleavage efficiency and reducing viral RNA-associated chemokines.

Cell wall thickness has phylogenetically consistent effects on photosynthetic N-use efficiency of land species

The paper investigates the factors influencing photosynthetic nitrogen-use efficiency (PNUE) across 679 C3 species, finding that cell wall thickness and other traits explain most of the variation in PNUE.

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

Nucleocapsid 203 mutations enhance SARS-CoV-2 immune evasion

This study shows that the nucleocapsid 203 mutation, combined with spike L452R, enhances SARS-CoV-2 immune evasion and fitness, contributing to the dominance of variants like Delta and Omicron.

Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection

This study identifies unconventional secretion of unglycosylated ORF8 as critical for inducing cytokine storms during SARS-CoV-2 infection by interacting with IL17RA on macrophages.

Explicit expression of mesophyll conductance in the traditional leaf photosynthesis-transpiration coupled model and its physiological significances

This study develops a photosynthesis-transpiration coupled model that explicitly incorporates mesophyll conductance, improving predictions of leaf gas exchange by optimizing parameterization methods.

LENG8 regulation of mRNA processing, is responsible for the control of mitochondrial activity

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

Nucleocapsid mutation R203K/G204R increases the infectivity, fitness and virulence of SARS-CoV-2

This study shows that the N protein mutations R203K/G204R increase SARS-CoV-2 infectivity, replication, and virulence, contributing to its spread and disease severity.

Programming large target genomic deletion and concurrent insertion via a prime editing-based method: PEDAR

The paper introduces PEDAR, a prime editing method that deletes and repairs genomic insertions, restoring gene function in a mouse model.

No observable guide-RNA-independent off-target mutation induced by prime editor

The paper investigates off-target mutations caused by prime editors and finds no observable gRNA-independent off-target effects in transfected human cells.

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

This paper improves prime editors for genome editing in adult mice, enabling pathogenic mutation correction and cancer modeling.

Characterization and description of Faecalibacterium butyricigenerans sp. nov. and F. longum sp. nov., isolated from human faeces

This paper describes two new species of Faecalibacterium isolated from human feces, supported by phylogenetic, genomic, and phenotypic analyses.

Taxonomic description and genome sequence of Christensenella intestinihominis sp. nov., a novel cholesterol-lowering bacterium isolated from human gut

This paper describes a new bacterial species, Christensenella intestinihominis, isolated from the human gut, and reports its cholesterol-lowering ability and exopolysaccharide production.

Butyribacter intestini gen. nov., sp. nov., a butyric acid-producing bacterium of the family Lachnospiraceae isolated from the human faeces, and reclassification of Acetivibrio ethanolgignens as Acetanaerobacter ethanolgignens gen. nov., comb. nov.

The paper describes the isolation and characterization of a new butyric acid-producing bacterium from human feces, and reclassifies another species within the same family.

Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

Tissue-specific Genome Editing in vivo by MicroRNA-repressible Anti-CRISPR Proteins

This paper develops a method to achieve tissue-specific genome editing in vivo using microRNA-repressible anti-CRISPR proteins to limit Cas9 activity to target tissues.

Preclinical Study: Sunitinib-suppressed MiR-452-5p Facilitates Renal Cancer Cell Invasion and Metastasis Through Modulating SMAD4/SMAD7/EMT Signals

This study identifies miR-452-5p as a key regulator of renal cancer metastasis, showing its upregulation and role in promoting invasion through SMAD4/SMAD7/EMT signaling.