Early cellular mechanism of type I interferon-driven susceptibility to tuberculosis
D. I. Kotov, O. V. Lee, S. A. Fattinger, C. Langner, J. V. Guillen, J. M. Peters, A. Moon, E. M. Burd, K. C. Witt, D. B. Stetson, D. L. Jaye, B. D. Bryson, R. E. Vance
This study identifies interstitial macrophages and plasmacytoid dendritic cells as key producers of type I IFN during Mtb infection, showing their role in driving tuberculosis pathogenesis through IFN-driven mechanisms.
bioRxiv · Oct 6, 2022Immunology