M. Mohiuddin

Preclinical study of the human recombinant Erythropoietin (GBPD002) compared with Eprex

This study compares the safety and toxicity of GBPD002 and Eprex(R), two recombinant human erythropoietins, in rats, finding similar toxicological profiles and no significant differences.

Determining the shelf life of an erythropoietin alfa biosimilar GBPD002 through stability study

This study evaluates the stability of the erythropoietin alfa biosimilar GBPD002 under various environmental conditions and determines its shelf life as 24 months.

Indigenous probiotics Lactobacillus reuteri and Enterococcus faecium exhibit positive growth performance and disease prevention against extended-spectrum cephalosporin and fluoroquinolones resistant Salmonella enterica in broiler chicks.

This study shows that indigenous probiotics Lactobacillus reuteri and Enterococcus faecium improve growth and reduce Salmonella infection in broiler chicks compared to commercial probiotics.

Development and qualification of a high-yield recombinant human Erythropoietin biosimilar

This paper develops and characterizes a high-yield biosimilar of recombinant human erythropoietin (rhEPO) that meets regulatory requirements and offers a cost-effective alternative.

A Cost-effective Purification Process for Erythropoietin Biosimilar through Downstream Process Engineering

This study develops a scalable and reproducible downstream purification process for EPO biosimilar, meeting quality requirements and reducing production costs.

BANCOVID, the first D614G variant mRNA-based vaccine candidate against SARS-CoV-2 elicits neutralizing antibody and balanced cellular immune response

This paper develops and characterizes an mRNA-LNP vaccine candidate targeting the D614G variant of SARS-CoV-2, showing neutralizing antibody and balanced cellular immune responses in preclinical trials.

Single Cell Deconstruction of Muscle Stem Cell Heterogeneity During Aging Reveals Sensitivity to the Neuromuscular Junction

The paper identifies a neuro-responsive subset of muscle stem cells that support neuromuscular junction integrity during aging and neurodegeneration.

Regenerating motor neurons prime muscle stem cells for myogenesis by enhancing protein synthesis and mitochondrial bioenergetics

This study shows that motor neurons enhance muscle stem cell function by boosting protein synthesis and mitochondrial activity, which is critical for muscle regeneration and is disrupted in diseases like muscular dystrophy and aging.

Transplantation of muscle stem cell mitochondria rejuvenates the bioenergetic function of dystrophic muscle

This study shows that transplanting healthy muscle stem cells into dystrophic muscle improves mitochondrial function and bioenergetics, while compromised stem cells fail to do so.

Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors

This study develops an in vitro muscle parabiosis system to identify rejuvenating factors in aged muscle stem cells by mimicking systemic and local signals.

Wnt7a-releasing synthetic hydrogel enhances local skeletal muscle regeneration and muscle stem cell engraftment

This paper develops a Wnt7a-releasing hydrogel to enhance skeletal muscle regeneration and stem cell engraftment in injured muscles.

Critical Limb Ischemia Induces Remodeling of Skeletal Muscle Motor Unit and Myonuclear- and Mitochondrial-Domains

This study investigates how critical limb ischemia affects skeletal muscle by increasing myonuclear number and mitochondrial content per myonucleus in mice.

Muscle Stem Cell Niche Dysregulation in Volumetric Muscle Loss Injury

This study investigates the effects of different-sized volumetric muscle loss injuries on muscle regeneration, finding that 3 mm injuries represent a critical threshold with significant fibrosis, inflammation, and impaired regeneration.