IGF targeting perturbs global replication through ribonucleotide reductase dysfunction
G. Rieunier, X. Wu, L. Harris, J. Mills, A. Nandakumar, L. Colling, E. Seraia, S. B. Hatch, D. Ebner, L. Folkes, U. Weyer-czernilofsky, T. Bogenrieder, A. J. Ryan, V. M. Macaulay
This study shows that IGF-1R inhibition causes replication stress by reducing RNR subunit RRM2, leading to DNA damage and synthetic lethality with ATM loss in cancer cells.
bioRxiv · Aug 11, 2020Cancer Biology