Author

V. M. Macaulay

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. J. Ryan· 1 shared A. Nandakumar· 1 shared D. Ebner· 1 shared E. Seraia· 1 shared G. Rieunier· 1 shared J. Mills· 1 shared L. Colling· 1 shared L. Folkes· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. J. Ryan

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1 paper

Recent·Most cited

Cancer BiologybioRxivAug 11, 2020

IGF targeting perturbs global replication through ribonucleotide reductase dysfunction

G. Rieunier, X. Wu, L. Harris…·V. M. Macaulay

This study shows that IGF-1R inhibition causes replication stress by reducing RNR subunit RRM2, leading to DNA damage and synthetic lethality with ATM loss in cancer cells.

DOI 10.1158/0008-5472.can-20-2860

humanDNA methylation

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