Author

S. B. Hatch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

D. Ebner· 4 shared C. I. Wells· 2 shared D. H. Drewry· 2 shared A. D. Axtman· 1 shared A. J. Ryan· 1 shared A. M. Syanda· 1 shared A. Nandakumar· 1 shared A. Picado· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCell Biology

D. Ebner

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Author profile →

4 papers

Recent·Most cited

Small molecule screen employing patient-derived iPS hepatocytes identifies LRRK2 as a novel therapeutic target for Alpha1 Antitrypsin Deficiency

D. Kent, S. S. Ng, P. Khoshkenar, A. M. Syanda, L. Chao Zheng, M. Zieger, C. Greer, S. B. Hatch, J. M. Segal, S. J. I. Blackford, V. Chowdary, T. Ismali, D. Danovi, S. Sahdeo, D. Ebner, , S. T. Rashid

A small molecule screen in patient iPSCs with in vivo validation in mice identifies LRRK2 as a new therapeutic target for Alpha-1 Antitrypsin Deficiency.

bioRxiv · Sep 17, 2021 · PreprintCell Biology

IGF targeting perturbs global replication through ribonucleotide reductase dysfunction

G. Rieunier, X. Wu, L. Harris, J. Mills, A. Nandakumar, L. Colling, E. Seraia, S. B. Hatch, D. Ebner, L. Folkes, U. Weyer-czernilofsky, T. Bogenrieder, A. J. Ryan, V. M. Macaulay

This study shows that IGF-1R inhibition causes replication stress by reducing RNR subunit RRM2, leading to DNA damage and synthetic lethality with ATM loss in cancer cells.

bioRxiv · Aug 11, 2020Cancer Biology

The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification

C. I. Wells, H. Al-Ali, D. M. Andrews, C. R. M. Asquith, A. D. Axtman, M. Chung, I. Dikic, D. Ebner, J. Elkins, P. Ettmayer, C. Fischer, M. Frederiksen, N. S. Gray, S. B. Hatch, S. Knapp, , D. H. Drewry

The paper introduces the Kinase Chemogenomic Set (KCGS), a curated collection of 187 selective kinase inhibitors covering 215 human kinases, for use in cell-based screens.

bioRxiv · Dec 22, 2019Cell Biology

Cyclin F-Chk1 synthetic lethality mediated by E2F1 degradation

V. D'Angiolella, H. Yang, R. Faedda, S. Hume, D. Ebner, S. B. Hatch, B. Kessler, K. Burdova, I. Vendrell, D. H. Drewry, C. I. Wells

The paper identifies synthetic lethality between Chk1 inhibition and cyclin F loss, revealing Cyclin F's role in preventing DNA replication stress via E2F1 degradation.

bioRxiv · Jan 2, 2019 · PreprintCancer Biology