Author

E. Seraia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Ebner· 2 shared A. J. Ryan· 1 shared A. Nandakumar· 1 shared C. Cooper· 1 shared C. Toffanin· 1 shared F. A. Okonjo· 1 shared F. Buffa· 1 shared G. D. D. Jones· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

D. Ebner

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Author profile →

2 papers

Recent·Most cited

Therapeutic targeting of SETD2-deficient cancer cells with the small-molecule compound RITA

K. A. Lopez, S. Sarkar, E. Seraia, C. Toffanin, C. Cooper, M. Challoumas, F. A. Okonjo, G. D. D. Jones, F. Buffa, D. Ebner, T. C. Humphrey

This paper identifies RITA as a compound that selectively kills SETD2-deficient cancer cells by inducing p53-mediated apoptosis and replication stress.

bioRxiv · Jul 8, 2021 · PreprintCell Biology

IGF targeting perturbs global replication through ribonucleotide reductase dysfunction

G. Rieunier, X. Wu, L. Harris, J. Mills, A. Nandakumar, L. Colling, E. Seraia, S. B. Hatch, D. Ebner, L. Folkes, U. Weyer-czernilofsky, T. Bogenrieder, A. J. Ryan, V. M. Macaulay

This study shows that IGF-1R inhibition causes replication stress by reducing RNR subunit RRM2, leading to DNA damage and synthetic lethality with ATM loss in cancer cells.

bioRxiv · Aug 11, 2020Cancer Biology