Cancer BiologybioRxivPreprint
Diet induced hyperlipidemia confers resistance to standard therapy in pancreatic cancer by selecting for "tumor protective" microbial metabolites and treatment refractory cells.
K. Kesh, R. Mendez, B. Mateo-Victoriano…·S. Banerjee
This study shows that a high-fat diet in pancreatic cancer mice increases resistance to chemotherapy by promoting microbial metabolites like queuosine, which protect tumors through PRDX1 upregulation, and this resistance can be reversed by S-adenosyl methionine.
DOI 10.1101/2021.01.12.426380