Prolonged β-Adrenergic Stimulation Disperses Ryanodine Receptor Clusters in Cardiomyocytes: Implications for Heart Failure
X. Shen, J. van den Brink, A. Bergan-Dahl, T. R. Kolstad, E. S. Norden, Y. Hou, M. Laasmaa, A. P. Quick, E. K. S. Espe, I. Sjaastad, X. Wehrens, A. Edwards, C. Soeller, W. E. Louch
This study shows prolonged β-adrenergic stimulation causes RyR cluster dispersion in cardiomyocytes, disrupting Ca2+ homeostasis and contributing to heart failure.
bioRxiv · Feb 18, 2022Cell Biology