Y. Hou

The RAE1-STOP1 Module Reduces Sensitivity to Exogenous ABA Treatment by Regulating ABI5 in Arabidopsis

The paper identifies the RAE1-STOP1 module as a negative feedback loop that reduces ABA sensitivity by preventing ABI5 upregulation in Arabidopsis.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu

This paper shows that estrogen receptor-α homodimers can function as conformational heterodimers, integrating different ligand signals to produce distinct agonist or antagonist activity profiles.

Single-cell transcriptional landscape of temporal neutrophil response to burn wound in larval zebrafish

This study maps the temporal neutrophil response to burn wounds in larval zebrafish, identifying distinct subsets and their interactions, and links zebrafish myeloid signatures to human burn severity.

Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide

This study identifies 16216 cisplatin-damaged genes in human lung cancer cells and shows cisplatin disrupts protein phosphorylation signalling by targeting 85% of protein kinase and 81% of phosphatase genes.

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

High-speed Auto-Polarization Synchronization Modulation Three-dimensional Structured Illumination Microscopy

This paper introduces a high-speed 3DSIM system using DMD and electro-optic modulators, achieving improved resolution and imaging speed for various biological specimens.

Comparative analysis of methodologies for detecting extrachromosomal circular DNA

This study compares 7 analysis pipelines and 7 experimental methods for detecting extrachromosomal circular DNA, identifying the most effective approaches for short-read and long-read sequencing data.

Alstrom Syndrome protein Alms1 is required for maintaining meiotic centriole engagement in spermatocytes of Drosophila

This study shows that Alms1 is essential for maintaining centriole engagement in Drosophila spermatocytes, with implications for understanding Alstrom Syndrome pathogenesis.

Cep290 is cooperatively maintained at basal body by Cep131-Cep162 and Cby-Fam92 modules

This study identifies two modules, Cep131-Cep162 and Cby-Fam92, that cooperatively maintain Cep290 at the basal body and initiate ciliogenesis.

Ser149 is another potential 14-3-3 epsilon binding site of Cdc25B in the G2/M transition of mouse fertilized eggs

This study identifies Ser149 as a 14-3-3 epsilon binding site on Cdc25B, showing its role in regulating G2/M transition in mouse fertilized eggs through phosphorylation and subcellular localization.

The super-pangenome of Populus unveil genomic facets for adaptation and diversification in widespread forest trees

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

A Gpr35 tuned gut-brain metabolic axis regulates depressive-like behavior

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.

Pathogen protein modularity enables elaborate mimicry of a host phosphatase

The paper identifies a modular (L)WY-LWY motif in Phytophthora effectors that recruits host PP2A phosphatase, enabling phosphoprotein regulation through structural mimicry.

High-efficiency base editing for Stargardt disease in mice, non-human primates, and human retina tissue

This study develops a base-editing strategy to correct the ABCA4 mutation in mice, non-human primates, and human retinal tissue, achieving high editing rates in vivo.

The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops

The paper identifies DDX1 as an interactor of the RNA exosome subunit EXOSC3 and shows that their interaction is reduced during DNA damage, affecting R-loop levels in neuronal cells.

Noise-robust, physical microscopic deconvolution algorithm enabled by multi-resolution analysis regularization

This paper introduces noise-robust deconvolution algorithms for fluorescence microscopy using multi-resolution analysis regularization, improving resolution and SNR across various imaging techniques.

High-throughput screening of functional neo-antigens and their specific TCRs via the Jurkat reporter system combine with droplet microfluidics

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo

This study reveals that neutrophils, not macrophages, primarily clear apoptotic hepatocytes through a novel process called perforocytosis, and defects in this process contribute to autoimmune liver disease.

Transient EZH2 suppression by Tazemetostat during in vitro expansion maintains T cell stemness and improves adoptive T cell therapy

The paper shows that transient EZH2 inhibition with Tazemetostat during T cell expansion maintains stemness and improves adoptive T cell therapy outcomes in a murine model.

Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.

The paper shows that loss of HD-PTP, a tumor suppressor, promotes RAS-driven oncogenesis and is associated with adenosquamous lung cancer, suggesting it as a therapeutic target.

A tessellated lymphoid network provides whole-body T cell surveillance in zebrafish

This paper identifies a novel lymphoid network in zebrafish that enables whole-body T cell surveillance without lymph nodes, supporting both collective migration and antigen search.

Protein aggregation in plant mitochondria inhibits translation and induces an NAC017-dependent ethylene-associated unfolded protein response

Lon1 knockout inhibits mitochondrial-encoded gene translation and induces retrograde signaling involving unfolded protein responses.

Open-3DSIM: an Open-source three-dimensional structured illumination microscopy reconstruction platform

Open-3DSIM improves lateral and axial resolution in 3D structured illumination microscopy and offers artifact suppression and defocus elimination across various specimens.

A novel non-invasive biomarker based on oral microbiome dysbiosis for detection of Community-Acquired Pneumonia

This study identifies oral microbiome dysbiosis as a non-invasive biomarker for detecting community-acquired pneumonia.

Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma

The paper identifies 4 immunoprognostic genes in ccRCC using bioinformatics analysis of public databases and validates their association with prognosis and immunotherapy response.

Sex differences in the nasal microbiome of healthy young adults

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editing

This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.

The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states

The paper analyzes chromatin landscapes of Th17 cell subsets to uncover regulatory mechanisms driving their heterogeneity and identifies BACH2 as a novel regulator of pathogenicity.

Prolonged β-Adrenergic Stimulation Disperses Ryanodine Receptor Clusters in Cardiomyocytes: Implications for Heart Failure

This study shows prolonged β-adrenergic stimulation causes RyR cluster dispersion in cardiomyocytes, disrupting Ca2+ homeostasis and contributing to heart failure.