A. Pelling

Plant Cellulose as a Substrate for 3D Neural Stem Cell Culture

This study shows that plant-derived cellulose scaffolds support NSC attachment, proliferation, and enhance differentiation into neuronal and astrocytic lineages compared to 2D culture.

Homemade Bread: Repurposing an Ancient Technology for in vitro Tissue Engineering

This paper develops and validates a yeast-free bread scaffold for in vitro cell proliferation, showing viability of fibroblasts, myoblasts, and pre-osteoblasts over four weeks.

Biomechanical study of cellulose scaffolds for bone tissue engineering in vivo and in vitro.

This study evaluates apple-derived cellulose scaffolds for bone tissue engineering, showing good biocompatibility and osteogenic potential but lower mechanical strength than native bone.

Mechanotransduction of strain regulates an invasive phenotype in newly transformed epithelial cells

This study shows that mechanical stretch promotes an invasive phenotype in transformed epithelial cells by altering actin dynamics and Rho-ROCK pathway activity.

Designer Scaffolds for Interfacial Bioengineering

This paper introduces engineered tissue interfaces (ETIs) made from modular plant-derived scaffolds to study interfacial tissue interactions and demonstrates their biocompatibility in vivo.

Time dependent stress relaxation and recovery in mechanically strained 3D microtissues

This study measures time-dependent stress relaxation and recovery in 3D microtissues under mechanical strain, finding stretched exponential behavior and a linear relationship between residual elasticity and stress relaxation.

Structural and mechanical remodeling of the cytoskeleton maintains tensional homeostasis in 3D microtissues under acute dynamic stretch

This study investigates how 3D microtissues maintain mechanical homeostasis under dynamic stretch by remodeling their cytoskeleton, showing strain softening and recovery without fluidization.

Decellularized Plant-Based Scaffolds for Guided Alignment of Myoblast Cells

This study uses decellularized celery scaffolds to guide the alignment of C2C12 myoblasts in vitro, showing that vascular bundle microtopography promotes aligned cell morphology and myotube formation.

Mechanical stretch sustains myofibroblast phenotype and function in microtissues through latent TGF-β1 activation

This study shows mechanical stretch maintains myofibroblast activation through latent TGF-β1 activation in microtissues, promoting fibrosis progression.

Mechanical mismatch between Ras transformed and untransformed epithelial cells.

This study examines how oncogenic Ras affects cell mechanics in adherent and suspended states, finding that it stiffens adherent cells and softens suspended cells.

A vacuum-actuated microtissue stretcher for long-term exposure to oscillatory strain within a 3D matrix

The paper introduces a microtissue stretcher device to study cellular responses to mechanical strain in 3D environments, showing reproducible strain delivery and increased F-actin expression under cyclic strain.