Cell BiologybioRxiv
A contraction stress model of hypertrophic cardiomyopathy due to thick filament sarcomere mutations
R. Cohn, K. Thakar, A. Lowe…·J. T. Hinson
This study uses CRISPR/Cas9 to create HCM iPSc models and finds that mutations cause hypercontractility and p53 activation linked to oxidative stress, suggesting p53 as a therapeutic target.
DOI 10.1016/j.stemcr.2018.11.015