A. Lowe

The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context

The paper compares immune responses to Trichuris muris in wild and laboratory mice, finding quantitative differences and age-specific effects in cytokine production and Th1/Th2 balance.

WY14643 Increases Herpesvirus Replication Independent of PPARα Expression and Inhibits IFNβ Production

This study shows that PPAR agonists like WY14643 increase herpesvirus replication and inhibit IFNβ production, independent of PPARα expression.

Cell-scale biophysical determinants of cell competition in epithelia

The paper constructs a multi-scale agent-based model to study cell competition in epithelia, finding that mechanical competition depends on homeostatic density differences while biochemical competition depends on tissue organisation.

Th2 Cytokine Modulates Herpesvirus Reactivation in a Cell Type Specific Manner

This study shows that IL-4 induces MHV68 reactivation in macrophages but not B cells, indicating cell-type specific regulation of herpesvirus reactivation.

Metabolic Control of Viral Infection through PPAR-α Regulation of STING Signaling

This study shows that PPAR-α activation increases herpesvirus replication, suppresses type I interferon, and inhibits STING signaling through ROS.

A contraction stress model of hypertrophic cardiomyopathy due to thick filament sarcomere mutations

This study uses CRISPR/Cas9 to create HCM iPSc models and finds that mutations cause hypercontractility and p53 activation linked to oxidative stress, suggesting p53 as a therapeutic target.