BiochemistrybioRxiv
HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA binding domain
E. E. Boczek, J. Fursch, L. Jawerth…·F. Stengel
This study identifies HspB8's role in preventing FUS condensate hardening by interacting with its RNA-binding domain, suggesting a mechanism to prevent neurodegenerative disease-associated phase transitions.
DOI 10.7554/elife.69377