Author

A. R. Gooding

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 3 Organism:human· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:cryo-EM· 1

Frequent Co-Authors

T. R. Cech· 4 shared V. Kasinath· 2 shared W. O. Hemphill· 2 shared C. I. Sousa· 1 shared J. J. Song· 1 shared J. L. Rinn· 1 shared J. Song· 1 shared L. I. Jansson-Fritzberg· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiochemistry

T. R. Cech

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4 papers

Recent·Most cited

BiochemistrybioRxivFeb 6, 2023

Structural basis for inactivation of PRC2 by G-quadruplex RNA

J. Song, A. R. Gooding, W. O. Hemphill…·T. R. Cech

The paper presents a cryo-EM structure of PRC2 bound to G-quadruplex RNA, revealing how RNA inhibits PRC2 by promoting dimerization and blocking DNA interaction.

DOI 10.1126/science.adh0059

cryo-EMexperimental assay

BiophysicsbioRxivPreprintNov 30, 2022

PRC2 direct transfer from G-quadruplex RNA to dsDNA: Implications for RNA-binding chromatin modifiers

W. O. Hemphill, R. Fenske, A. R. Gooding, T. R. Cech

This study reveals a direct transfer mechanism by which PRC2 exchanges RNA and DNA/nucleosome in its binding site, reconciling conflicting in vitro and in vivo findings on RNA's role in regulating PRC2 activity.

DOI 10.1101/2022.11.30.518601

biophysical modelingstatistical model

BiochemistrybioRxivOct 14, 2022

DNMT1 inhibition by pUG-fold quadruplex RNA

L. I. Jansson-Fritzberg, C. I. Sousa, M. J. Smallegan…·T. R. Cech

This study shows that DNMT1 interacts with pUG-fold RNA, which inhibits its activity by blocking DNA binding.

DOI 10.1261/rna.079479.122

humanmetagenomics

BiochemistrybioRxivJun 8, 2018

Regulation of histone methylation by automethylation of PRC2

X. Wang, Y. Long, R. D. Paucek…·T. R. Cech

This study identifies EZH2 automethylation as a regulatory mechanism that modulates PRC2 histone methyltransferase activity.

DOI 10.1101/gad.328849.119

humanChIP-seq