W. O. Hemphill

The paper presents a cryo-EM structure of PRC2 bound to G-quadruplex RNA, revealing how RNA inhibits PRC2 by promoting dimerization and blocking DNA interaction.

The paper demonstrates that RNA- and DNA-binding proteins can directly transfer polynucleotides, enabling one-dimensional target site search and suggesting regulated complex lifetimes in vivo.

This study reveals a direct transfer mechanism by which PRC2 exchanges RNA and DNA/nucleosome in its binding site, reconciling conflicting in vitro and in vivo findings on RNA's role in regulating PRC2 activity.

This paper shows Varroa destructor steals intact host proteins for rapid development and reproduction, describing this as 'kleptocytosis'.

This study investigates TREX1 exonuclease activity, revealing its preference for double-strand DNA and inter-protomer regulation through biochemical assays, simulations, and modeling.