A. R. Walker

Spatial targeting of the prostaglandin receptor EP2 to very early endosomes co-ordinates PGE2-mediated cAMP signaling in decidualizing human endometrium

The paper shows that PGE2's spatial targeting to very early endosomes is crucial for coordinating cAMP signaling in decidualizing human endometrium.

Glucose PTS Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci

This study shows that glucose PTS mutants in oral streptococci alter pyruvate metabolism, enhancing acid tolerance and interspecies interactions, which impacts microbial ecology and dental caries.

Activation of TnSmu1, an integrative and conjugative element, by an ImmR-like transcriptional regulator in Streptococcus mutans

This study identifies a regulatory module controlling TnSmu1 activation in Streptococcus mutans, showing its deleterious effects on bacterial physiology.

Spontaneous Mutants of Streptococcus sanguinis with Defects in the Glucose-PTS Show Enhanced Post-Exponential Phase Fitness

The paper identifies glucose-PTS mutants in Streptococcus sanguinis that show enhanced survival in acidic conditions and improved inhibition of Streptococcus mutans.

Amino Sugars Reshape Interactions between Streptococcus mutans and Streptococcus gordonii.

This study investigates how amino sugars like GlcN and GlcNAc affect gene expression and interactions between Streptococcus mutans and Streptococcus gordonii, revealing significant transcriptomic changes and metabolic reprogramming.

Repurposing the Streptococcus mutans CRISPR-Cas9 System to Understand Essential Gene Function

The paper develops a CRISPR interference tool for Streptococcus mutans to study essential genes, identifying growth defects and phenotypes in 77% of targeted strains.

Exploring novel probiotic mechanisms of Streptococcus A12 with functional genomics

This study identifies molecular mechanisms by which Streptococcus A12 competes with S. mutans using functional genomics and gene deletion analysis.