L. Zeng

Systematic Analysis of the Glucose-PTS in Streptococcus sanguinis Highlighted its Importance in Central Metabolism and Bacterial Fitness

This study investigates the role of the glucose-PTS in Streptococcus sanguinis, showing its impact on bacterial fitness, acid production, and antagonism against S. mutans.

Glycerol Metabolism Contributes to Competition by Oral Streptococci through Production of Hydrogen Peroxide

This study shows that glycerol metabolism in oral commensal streptococci produces hydrogen peroxide, enhancing competition against the pathogen Streptococcus mutans.

Coxsackievirus group B3 regulates ASS1-mediated metabolic reprogramming and promotes macrophage inflammatory polarization in viral myocarditis

This study shows CVB3 infection upregulates ASS1 through citrulline consumption, leading to metabolic reprogramming and macrophage inflammatory polarization, contributing to viral myocarditis.

The molecular basis of pine wilt disease resistance in Pinus massoniana

This study identifies three molecular resistance strategies in Pinus massoniana cultivars against pine wood nematodes using transcriptome and metabolome profiling.

Virus-derived Synthetic Riboswitches for Real-time Coronaviruses Sensing in Live Cells

This paper develops a viral riboswitch system for real-time coronavirus detection and antiviral response in live cells, showing effectiveness against 229E and OC43.

Warfarin analogs target disulfide bond-forming enzymes and suggest a residue important for quinone and coumarin binding

The paper identifies a conserved residue critical for quinone and coumarin binding in disulfide bond-forming enzymes and demonstrates the potential of warfarin analogs as anticoagulants or antibacterials.

Mutations in HUA2 restore flowering in the Arabidopsis trehalose 6-phosphate synthase1 (tps1) mutant

This study identifies HUA2 mutations that restore flowering and embryogenesis in the tps1-2 GVG::TPS1 Arabidopsis mutant by modulating carbohydrate signaling and activating flowering regulators.

Chlamydial protease-like activating factor targets SLC7A11 for degradation to induce ferroptosis and facilitate dissemination.

This study identifies CPAF-mediated degradation of SLC7A11 as a mechanism for Chlamydia-induced ferroptosis, promoting bacterial dissemination and suggesting therapeutic targeting.

Spatial propagation of temperate phages within and among biofilms

The paper tracks temperate phages in biofilms, showing lysogens are over-represented in dispersal pools and have advantages in long-term propagation.

A novel nested gene Aff3ir participates in vascular remodelling by enhancing endothelial cell differentiation in mice

This study identifies Aff3ir as a novel gene involved in endothelial cell differentiation by enhancing vascular stem/progenitor cell differentiation in mice.

IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers

This study shows that adding intrinsically disordered regions (IDRs) to CARs improves their cytotoxicity against low-antigen cancers by enhancing signaling and killing activity.

Human TUBA1B short open reading frame product regulates cancer cell growth via importin-β

This study identifies TUBA1B-sORF1, a novel protein from the TUBA1B gene, which promotes cancer cell growth by facilitating nuclear translocation of β-catenin.

Modifications of Two ESCRT-I Subunits with Distinct Ubiquitin Chains Regulate Plant Immunity

The paper shows that XBAT35.2 modulates FLS2 stability by ubiquitinating ESCRT-I subunits VPS37-1 and VPS28-2 with distinct ubiquitin chains, enhancing plant immunity.

Genetic Characterization of Glyoxalase Pathway in Oral Streptococci and its Contribution to Interbacterial Competition

This study investigates the glyoxalase pathway in oral streptococci, showing Streptococcus mutans has greater RES tolerance and competitiveness compared to Streptococcus sanguinis.

Co-infecting phages impede each other's entry into the cell

The paper shows co-infecting phages impede each other's entry into cells, revealing MOI-dependent host physiological changes that affect infection outcomes.

RNA sequencing identifies lung cancer lineage and facilitates drug repositioning

This paper uses RNA sequencing to classify lung cancer subtypes and identifies drug repositioning opportunities based on lineage-specific responses.

QCR7 affects the virulence of Candida albicans and the uptake of multiple carbon sources present in different host niches

Glucose PTS Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci

This study shows that glucose PTS mutants in oral streptococci alter pyruvate metabolism, enhancing acid tolerance and interspecies interactions, which impacts microbial ecology and dental caries.

Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity

This study uses human blood vessel organoids to show that CTGF is critical for maintaining microvascular integrity under metabolic stress.

Impaired Function in Diabetic Patient iPSCs-derived Blood Vessel Organoids Stem from a Subpopulation of Vascular Cells

This study identifies impaired vascular function in diabetic iPSCs-derived blood vessel organoids, highlighting a subpopulation of endothelial cells with increased ROS and oxidative phosphorylation.

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D

This study shows SARS-CoV-2 evades NK cell killing by downregulating NKG2D ligands via Nsp1, reducing NK cell cytotoxicity against infected cells.

Cells with Stochastically Increased Methyltransferase to Restriction Endonuclease Ratio Provide an Entry for Bacteriophage into Protected Cell Population

The paper shows that altering the MTase to REase ratio in bacterial cells affects phage infection resistance, with higher ratios correlating with increased susceptibility.

Gnas ablation in CD11c+ cells prevents high-fat diet-induced obesity by elevating adipose tissue catecholamine levels and thermogenesis

A plastidial retrograde-signal potentiates biosynthesis of systemic stress response activators

The paper identifies MEcPP as a plastidial retrograde signal that initiates a cascade leading to the biosynthesis of systemic stress response activators in response to biotic and abiotic stresses.

ORA47 is a transcriptional regulator of a general stress response hub

The paper identifies ORA47 as a transcriptional regulator involved in the general stress response by interacting with the RSRE motif and functioning with CAMTA3 and JAZ1.

Translation rescue by targeting Ppp1r15a upstream open reading frame in vivo

This study shows that targeting the Ppp1r15a upstream open reading frame rescues translation and improves kidney function in sepsis by overcoming uORF-mediated repression.

A MYB transcription factor, PlMYB308, plays an essential role in flower senescence of herbaceous peony

This study identifies PlMYB308 as a key regulator of flower senescence in herbaceous peony by modulating hormone levels and anthocyanin biosynthesis.

Two Ubiquitin-Activating Systems Occur in Plants with One Playing a Major Role in Plant Immunity

The paper identifies two ubiquitin-activating systems in plants, showing that one E1 plays a major role in plant immunity by differentially charging ERAD-associated E2s for ER stress tolerance.

A universal microfluidic approach for quantitative study of bacterial biofilms

The paper introduces a universal microfluidic method for studying bacterial biofilms, demonstrating insights into H2O2 resistance and resource retention mechanisms in E. coli and P. aeruginosa biofilms.

Tunable Cellular Localization and Extensive Cytoskeleton-Interplay of Reflectins

This study investigates the cellular localization and cytoskeleton interactions of reflectin proteins, revealing their localization preferences and potential mechanisms for nuclear entry and cytoskeletal binding.