RNF43 is a gatekeeper for colitis-associated cancer
A. Dietl, A. Ralser, K. Taxauer, T. Dregelies, W. Sterlacci, M. Stadler, R. Olayo-Alarcon, S. Margaryan, M. Skerhut, T. Groll, K. Steiger, D. Singh, X. Li, R. Oellinger, R. Rad, , R. Mejias Luque
This study identifies RNF43 mutations as a driver of colitis-associated cancer by showing their role in promoting inflammation and dysbiosis in mouse models and human patients.
bioRxiv · Jan 30, 2024 · PreprintCancer Biology