D. Singh

SMAS: Structural MRI-Based AD Score using Bayesian VAE

This paper introduces SMAS, a Bayesian VAE-based AD score from structural MRI data, showing strong correlations with cognitive decline and brain atrophy markers, and outperforming existing measures in predicting AD.

Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis

This study identifies physical interactions between septins and the exocyst complex in fission yeast, showing septins guide exocyst localization for proper cytokinesis.

MYB transcription factor, NtMYB308, regulates anthocyanin and lignin content, and fungal tolerance in tobacco

This study identifies NtMYB308 as a negative regulator of anthocyanin and lignin biosynthesis in tobacco, which influences fungal tolerance.

High-order Michaelis-Menten equations allow inference of hidden kinetic parameters in enzyme catalysis

The paper derives high-order Michaelis-Menten equations to infer hidden kinetic parameters in enzyme catalysis from single-molecule data.

Phosphorylation of KRP3, a KIP-related protein by MPK3 modulates rice tiller and seed number by fine-tuning cell division

This study identifies KRP3 as a phosphorylation target of MPK3, showing that their interaction modulates rice tiller and seed number by regulating cell division.

Guava cv. Allahabad Safeda Chromosome scale assembly and comparative genomics decodes breeder choice marker trait association for pink pulp colour

The paper presents a chromosome-scale guava genome assembly and identifies a gene associated with pink pulp color through comparative genomics and marker-trait association analysis.

The Molecular Architecture of the Nuclear Basket

This study uses structural biology to reveal the architecture of the nuclear basket in yeast and mammals, showing how Mlp/Tpr proteins form its structural components.

HY5 and COP1 function antagonistically in the light-dependent regulation of nicotine biosynthesis in tobacco

This study shows that HY5 and COP1 antagonistically regulate light-dependent nicotine biosynthesis in tobacco by modulating shoot-to-root transport of HY5.

RNF43 is a gatekeeper for colitis-associated cancer

This study identifies RNF43 mutations as a driver of colitis-associated cancer by showing their role in promoting inflammation and dysbiosis in mouse models and human patients.

Identifying the genetic and epigenetic basis for asymmetric bZIP expression in temperature-stressed bread wheat

This study investigates the genetic and epigenetic factors underlying asymmetric bZIP expression in bread wheat under temperature stress.

Tracing India's Canine Heritage through SNP-Based Haplotype Identification

The paper identifies haplotypes and explores population structure in Indian dog breeds using SNP data, revealing genetic connections between breeds from Punjab and Haryana.

Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic transport

The paper constructs an integrative Brownian dynamics model of nucleocytoplasmic transport, revealing how FG repeat proteins and nuclear transport receptors mediate selective transport through NPCs.

MPK4 mediated phosphorylation of PIF4 controls thermosensing by regulation of H2A.Z deposition in Arabidopsis

This study shows that MPK4 phosphorylates PIF4, which regulates ARP6 and H2A.Z deposition to control thermosensing in Arabidopsis.

A broadly protective CHO cell expressed recombinant spike protein subunit based vaccine (IMT-CVAX) against SARS-CoV-2

This paper develops a recombinant spike protein subunit vaccine (IMT-CVAX) against SARS-CoV-2 that elicits broad neutralization against variants and provides protection in animal models.

System analysis of differentially expressed miRNAs in hexaploid wheat display tissue-specific regulatory role during Fe deficiency response

The paper identifies Fe deficiency-responsive miRNAs in hexaploid wheat and shows their tissue-specific regulation and potential targets involved in Fe homeostasis.

Emergent dynamics of underlying regulatory network links EMT and androgen receptor-dependent resistance in prostate cancer

The paper models a regulatory network linking EMT and AR resistance in prostate cancer, identifying four phenotypes and showing stochastic switching between states.

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

MicroProteins miP1b/BBX30 and miP1a/BBX31 form a positive feedback loop with ABI5 to retard seedling establishment

The paper identifies a positive feedback loop between ABI5 and microProteins miP1a/BBX31 and miP1b/BBX30 that delays seedling establishment under unfavorable conditions.

Transcriptional signature pattern in black, blue and purple wheat and impact on seed pigmentation and other associated features: Comparative transcriptomics, genomics and metabolite profiling

The paper investigates anthocyanin biosynthesis in pigmented wheat seeds using transcriptomics, genomics, and metabolite profiling to identify gene regulation patterns and their impact on seed color and traits.

Elongated Hypocotyl 5 (HY5) regulates BRUTUS (BTS) to maintain Iron homeostasis in Arabidopsis thaliana.

This study shows HY5 regulates Fe deficiency responses in Arabidopsis by modulating BTS and Fe uptake genes.

Spatiotemporal patterning enabled by gene regulatory networks

The paper investigates how spatiotemporal patterns emerge from synthetic gene regulatory networks with diffusion in 1D and 2D space, analyzing stability and diffusion effects.

Reward quantity discrimination in an associative learning task in wild zebrafish (Danio rerio)

This study tests reward quantity discrimination in wild zebrafish using an operant conditioning task and finds some fish can discriminate between stimuli associated with different rewards.

Mutation in shoot-to-root mobile transcription factor, ELONGATED HYPOCOTYL 5, leads to low nicotine levels in tobacco

This study shows that mutation in the shoot-to-root mobile transcription factor NtHY5 reduces nicotine levels in tobacco by down-regulating the biosynthetic pathway in root tissues.

Continuum Theory for Planar Cell Polarity

This paper develops a continuum model to explain how planar cell polarity (PCP) proteins localize asymmetrically on cell membranes and how tissue-level expression gradients stabilize PCP.

Lattice-based microenvironmental uncertainty driven phenotypic decision-making: a comparison with Notch-Delta-Jagged signaling

The paper develops a lattice-based agent model driven by microenvironmental uncertainty to study multicellular phenotypic decision-making, comparing it with Notch-Delta-Jagged signaling.

Identification of mRNAs that undergo stop codon readthrough in Arabidopsis thaliana

This study identifies 144 Arabidopsis thaliana genes undergoing stop codon readthrough using ribosome profiling and experimental validation, revealing functional implications for protein localization and plant physiology.

Comprehensive Structure and Functional Adaptations of the Yeast Nuclear Pore Complex

This study presents the structure of the yeast nuclear pore complex using cryo-EM, revealing its functional adaptations and evolutionary links.

Surface expressed Plasmodium circumsporozoite protein (CSP) modulates cellular flexibility and motility

This study shows that Plasmodium circumsporozoite protein (CSP) modulates cellular flexibility and motility in Dictyostelium cells and correlates with sporozoite stiffness in Plasmodium berghei.

Baseline cell proliferation rates and response to UV differ in Lymphoblastoid Cell Lines derived from healthy individuals of extreme constitution types

The paper compares baseline cell proliferation rates and UV response in Lymphoblastoid Cell Lines from healthy individuals with different constitution types, finding significant differences in proliferation and recovery.

A viral genome packaging ring-ATPase is a flexibly coordinated pentamer

The paper determines the composition of the bacteriophage T4 DNA packaging motor and shows that it can tolerate an inactive subunit, challenging the idea of strict coordination among motor subunits.