S. Luo

Loss of H3K9 trimethylation leads to premature aging

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

Non-additivity of the functional properties of individual P450 species and its manifestation in the effects of alcohol consumption on the metabolism of ketamine and amitriptyline

The paper investigates how alcohol affects drug metabolism by analyzing interactions between P450 enzymes in human liver microsomes, finding alcohol increases low-affinity enzyme roles and alters enzyme-specific metabolic rates.

Protocatechuic acid induces endogenous oxidative stress in CR-hvKP by regulating the EMP-PPP pathway

This study shows that protocatechuic acid (PCA) enhances antibiotic efficacy against carbapenem-resistant hypervirulent Klebsiella pneumoniae by inducing oxidative stress through regulation of the EMP-PPP pathway.

Supercontinuum intrinsic fluorescence imaging heralds free view of living systems

This paper introduces a supercontinuum fluorescence imaging technique that enables non-invasive, high-content analysis of living systems across multiple biological processes and species.

Targeted LNPs deliver mRNA encoding IL-15 superagonists to balance efficacy and toxicity in cancer therapy

This study uses targeted mRNA-LNPs to deliver IL-15 superagonists, improving anti-tumor efficacy while reducing toxicity compared to existing therapies.

An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

This study establishes a mouse model using GX_P2V(short_3UTR) to evaluate drug and vaccine efficacy against SARS-CoV-2.

Comparative analysis of methodologies for detecting extrachromosomal circular DNA

This study compares 7 analysis pipelines and 7 experimental methods for detecting extrachromosomal circular DNA, identifying the most effective approaches for short-read and long-read sequencing data.

A novel gapmer nanobiosensor for probing long noncoding RNAs (lncRNA) expression dynamics during osteogenic and adipogenic differentiation

This study develops a ds-GapM-LNA nanobiosensor to visualize lncRNA expression in live hMSCs, revealing MALAT1 dynamics during osteogenic and adipogenic differentiation.

A partial Drp1 knockout improves autophagy flux independent of mitochondrial function

This study shows that partial Drp1 knockout enhances autophagy flux without affecting mitochondrial function, revealing a distinct protective mechanism against manganese toxicity.

A novel simian adenovirus vectored COVID-19 vaccine elicits effective mucosal and systemic immunity in mice by intranasal and intramuscular vaccination regimens

This paper evaluates a novel simian adenovirus vectored COVID-19 vaccine, showing that intranasal vaccination induces stronger mucosal immunity while intramuscular vaccination enhances systemic immunity, with combined regimens providing long-term protection.

Enhanced Branched-Chain Amino Acid Metabolism Improves Age-related Reproductive Function

This study shows that enhancing branched-chain amino acid metabolism improves reproductive function in aging C. elegans by maintaining oocyte quality.

Single cell DNA methylation ageing in mouse blood

This study develops a single-cell DNA methylation age predictor using a large multi-omics dataset from mouse blood, revealing epigenetic age heterogeneity and differences across blood cell types.

Investigation of a mathematical model describing global cancer growth and treatment: An inhomogeneous model based on the generalized logistic equation

This paper introduces an inhomogeneous mathematical model based on the generalized logistic equation to describe tumor growth and treatment, validated against clinical observations and theories of tumor heterogeneity.

The protist ubiquitin ligase effector PbE3-2 targets RD21A to impede plant immunity

This study identifies PbE3-2, a protist effector that degrades RD21A to suppress plant immunity, contributing to clubroot disease.

Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody Precursors

This paper introduces new mouse models expressing human HIV-1 broadly neutralizing antibody (bnAb) precursors with more physiological levels and diversity, enhancing vaccine research for bnAb elicitation.

Altered virome structrue and function characterization in Helicobacter pylori-driven colorectal carcinogenesis and H. pylori eradication

This study characterizes changes in the gut virome during H. pylori-driven colorectal carcinogenesis and after eradication, showing expanded temperate phages and persistent antibiotic resistance genes.

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

The paper describes a humanized antibody, SP1-77, that neutralizes all SARS-CoV-2 variants by blocking membrane fusion instead of ACE2 receptor binding.

A self-blinking DNA probe for 3D superresolution imaging of native chromatin

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell Leukemia

This paper identifies a NOTCH1-SIRT1-KAT7 axis in T-ALL that promotes leukemia and resistance to therapy, suggesting new therapeutic targets.

Tree diversity effects on productivity depend on mycorrhizae and life strategies in a temperate forest experiment

The paper examines how tree diversity affects productivity in a temperate forest, finding that mycorrhizal types (AM and EM) influence biodiversity-ecosystem functioning relationships differently.

Increasing plant group productivity through latent genetic variation for cooperation

The paper identifies a genetic locus that promotes cooperation in plant stands, increasing productivity in high-density monocultures by reducing root competition and enhancing disease resistance.

Fertilizer reduction with bio-organic fertilizer to regulate the root soil microbial community structure to improve Baby Chinese cabbage yield

This study investigates how reducing chemical fertilizers and adding bio-organic fertilizer affects soil microbial communities and Baby Chinese cabbage yield in Gansu plateau, finding that T2 treatment yields the highest crop output.

A highly attenuated SARS-CoV-2 related pangolin coronavirus variant has a 104nt deletion at the 3'-terminus untranslated region

This study identifies a highly attenuated SARS-CoV-2 related pangolin coronavirus variant with a 104nt deletion in the 3'-UTR HVR, showing reduced virulence in vitro and in vivo.

Diet outweighs genetics in shaping gut microbiomes in Asian honeybee

This study shows that diet, particularly pollen polysaccharides, has a greater impact on shaping gut microbiomes in Asian honeybees than genetics.

Amplicon sequencing of single-copy protein-coding genes reveals accurate diversity for sequence-discrete microbiome populations

This paper develops a pipeline to identify single-copy protein-coding genes for accurately quantifying sequence-discrete populations in microbial communities, validated using Gilliamella in honeybee guts.

Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Dextran Sodium Sulfate-Induced Ulcerative Colitis

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

The cytokine receptor DR3 identifies and activates thymic NKT17 cells

This study identifies DR3 as a surface marker for thymic NKT17 cells and shows it activates these cells in vivo and in vitro.

FGF21 Response Varies by Sugar Type and is Associated with Body Weight, Dietary Added Sugar, and Neural Signaling in Humans

This study shows that FGF21 levels vary with sugar type and are linked to body weight, dietary sugar intake, and brain signaling in humans.

TIC236 gain-of-function mutations unveil the link between plastid division and plastid protein import

This study identifies TIC236 gain-of-function mutations that enhance plastid protein import and reveal their role in plastid division and plant stress response.

The Coxiella burnetii QpH1 plasmid is a virulence factor for colonizing bone marrow-derived murine macrophages

This study shows that the QpH1 plasmid in Coxiella burnetii is essential for colonizing murine macrophages and highlights its role in the bacterium's persistence in rodents.