K. Steiger

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

RNF43 is a gatekeeper for colitis-associated cancer

This study identifies RNF43 mutations as a driver of colitis-associated cancer by showing their role in promoting inflammation and dysbiosis in mouse models and human patients.

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease

The paper shows mitochondrial dysfunction in intestinal epithelium leads to microbiota-dependent injury and identifies gene signatures that distinguish active from inactive inflammation in IBD.

NF-κB c-REL-OTUD4 axis regulates B-cell receptor in B-cell lymphoma

The paper identifies the c-REL-OTUD4 axis as a regulator of BCR in B-cell lymphoma, showing OTUD4 stabilizes c-REL and BCR, and its downregulation inhibits lymphoma cell growth.

Gut microbial disruption in critically ill patients with COVID-19 associated pulmonary aspergillosis

This study investigates the gut and bronchial microbiota in critically ill COVID-19 patients with and without CAPA, finding reduced gut diversity and increased Staphylococcus epidermidis in CAPA patients.

Intestinal myofibroblasts regulate intestinal epithelial cell plasticity via YAP/TAZ

This study shows that intestinal myofibroblasts enhance enteroid self-renewal and survival through YAP/TAZ signaling and TGF-β, without involving Wnt.

Transcriptionally defined morphological subtypes of pancreatic ductal adenocarcinoma

The paper identifies five transcriptional subtypes of PDAC cells with distinct morphological patterns and confirms their prognostic significance using bulk RNA-sequencing datasets.

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltration

This study identifies RNA as a significant source of tumor-agnostic neoantigens, which correlate with T-cell infiltration in multiple cancer types.

B/T cell crosstalk and aberrant inflammatory IgG exacerbate autoimmune intestinal inflammation

This study identifies B cell-driven inflammatory mechanisms, including aberrant IgG production and CD86-mediated T cell activation, as contributors to exacerbated intestinal inflammation in IBD.

A translational swine model for Crohn`s disease

This paper develops a genome-edited swine model of Crohn's disease that replicates key human disease features to enable translational research.

Acinar-to-ductal metaplasia in the pancreas requires a glycolytic switch and functional mitochondria

This study identifies a glycolytic switch and functional mitochondria as essential for acinar-to-ductal metaplasia, a key step in pancreatic carcinogenesis.

Gut Bacterial Dysbiosis and Instability is Associated with the Onset of Complications and Mortality in COVID-19

The paper analyzes gut and oral microbiota in COVID-19 patients to show associations between microbial dysbiosis, complications, and mortality.

Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

The paper characterizes neoantigen-specific T-cell receptors in a melanoma patient, showing that low-avidity TCRs can provide effective anti-tumor responses and persist long-term in blood and tissues.

Porcine model elucidates function of p53 isoform in carcinogenesis

This study uses a porcine model to show that specific p53 isoforms and circular TP53 RNA drive tumorigenesis, particularly osteosarcoma, in pigs and likely have similar roles in humans.

Exosomes transmit retroelement RNAs to drive inflammation and immunosuppression in Ewing Sarcoma

This study identifies retroelement RNAs in Ewing Sarcoma exosomes that induce inflammation and immunosuppression in recipient cells.