Bacterial ADP-heptose initiates a revival stem cell program in the intestinal epithelium
S. Goyal, C. X. Guo, A. Ranger, D. K. Tsang, O. Singh, C. F. Harrigan, O. Zaslaver, H. Rost, H. Y. Gaisano, S. Yuzwa, N. Gao, J. L. Wrana, D. J. Philpott, S. D. Gray-Owen, S. Girardin
This study shows that bacterial ADP-heptose triggers a revival stem cell program in the intestinal epithelium by inducing Paneth cell dedifferentiation and ISC loss.
bioRxiv · Jan 15, 2024 · PreprintCell Biology