S. Goyal

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

Bacterial ADP-heptose initiates a revival stem cell program in the intestinal epithelium

This study shows that bacterial ADP-heptose triggers a revival stem cell program in the intestinal epithelium by inducing Paneth cell dedifferentiation and ISC loss.

Limitations and Optimizations of Cellular Lineages Tracking

This paper examines the trade-off between lineage tracking accuracy and the number of traceable lineages in barcode-based methods and discusses optimal experimental design.

Promoting diversity in ecological systems through toxin production

The paper models how toxin production in microbial communities can promote diversity by integrating resource partitioning and toxin sensitivity trade-offs.

Improved Yield for the Enzymatic Synthesis of Radiolabeled Nicotinamide Adenine Dinucleotide

The paper improves the enzymatic synthesis of radiolabeled NAD+ with a 98% yield using lower reactant concentrations and standard equipment.

Dynamics of Mitochondrial NAD+ Import Reveal Preference for Oxidized Ligand and Substrate Led Transport

This study identifies the ligand binding site for SLC25A51, a mitochondrial NAD+ importer, and shows how lipid interactions and electrostatic forces regulate its transport mechanism.

The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition

The paper identifies ELF3 as an epithelial-associated transcription factor that inhibits EMT and stabilizes hybrid E/M phenotypes, with potential prognostic implications in solid tumors.

Dynamics of immune memory and learning in bacterialcommunities

This study develops a model of CRISPR-based adaptive immunity in microbes to explore immune memory, coevolution, and cross-reactivity, revealing parallels with vertebrate adaptive immunity.

3D-Printing in Radiation Oncology: Development and Validation of Custom 3D-Printed Brachytherapy Alignment Device and Phantom

This paper develops and validates a 3D-printed brachytherapy alignment device and anatomical phantom using patient CT data to improve needle alignment accuracy in radiation oncology.

Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma

This study characterizes the minimal residual disease state in glioblastoma, revealing distinct evolutionary trajectories and immunomodulatory signatures associated with recurrence.

Contingency and selection in mitochondrial genome dynamics

This study tracks mtDNA mutational trajectories in yeast using long-read sequencing, revealing new patterns in mtDNA fragmentation and fitness dynamics.

Vps501, a novel vacuolar SNX-BAR protein cooperates with the SEA complex to induce autophagy

This study identifies Vps501 as a novel SNX-BAR protein that cooperates with the SEA complex to regulate autophagy in yeast.

A dynamical systems treatment of transcriptomic trajectories in hematopoiesis

This paper applies a dynamical systems framework to transcriptomic data from hematopoiesis, identifying bifurcations in neutrophil differentiation and uncovering key gene contributors.

Flapping, swirling and flipping: Non-linear dynamics of pre-stressed active filaments

This study investigates the non-linear dynamics of pre-stressed active filaments under follower forces and fluid drag, revealing oscillatory instabilities and three-dimensional swirling patterns.

Thioesterase Superfamily Member 1 Undergoes Stimulus-coupled Reorganization to Regulate Metabolism

This paper shows that Them1 undergoes conformational changes in response to stimuli, forming biomolecular condensates that regulate fatty acid oxidation and thermogenesis.

The size of the immune repertoire of bacteria

The paper examines the trade-off between the size of the bacterial immune repertoire and the effectiveness of response to phage threats, showing how this limits the optimal size of CRISPR cassettes.