N. Gao

Early-life Microbiome-Derived HCA Enhances Type 3 Immunity via FXR-dependent m6A RNA methylation

Molecular mechanism of the flotillin complex in membrane microdomain organization

This study determines the cryo-EM structure of the flotillin complex, revealing its role in membrane microdomain organization and phosphorylation-regulated assembly.

Bacterial ADP-heptose initiates a revival stem cell program in the intestinal epithelium

This study shows that bacterial ADP-heptose triggers a revival stem cell program in the intestinal epithelium by inducing Paneth cell dedifferentiation and ISC loss.

Interferon epsilon restricts Zika virus infection in the female reproductive tract

This study shows that IFNε protects against vaginal ZIKV infection in mice by maintaining epithelial integrity and is effective even without IFNAR1 signaling.

Structural basis for BIRC6 to balance apoptosis and autophagy

This study reveals the structural basis of BIRC6's role in balancing apoptosis and autophagy by showing its dimeric structure and interactions with Smac/DIABLO, caspase 3, HtrA2, and LC3.

Cryo-EM Structure of the 50S-HflX Complex Reveals a Novel Mechanism of Antibiotic Resistance in E. coli

The paper presents a cryo-EM structure of the E. coli 50S-HflX complex, revealing how HflX interacts with the ribosome and contributes to antibiotic resistance by displacing antibiotics from the peptidyl transferase center.

Structural and Functional Insights into the Action Mode of A Mitochondrial AAA+ Disaggregase CLPB

The paper was withdrawn due to duplicate posting and is no longer available for citation.

Triple Notch/Tgfβ/FoxO1 blockade converts multiple intestinal sub-lineages into β-like cells and lowers glycemia in diabetic animals

Atomic-Resolution Prediction of Degrader-mediated Ternary Complex Structures by Combining Molecular Simulations with Hydrogen Deuterium Exchange

This paper predicts atomic-resolution structures of degrader-mediated ternary complexes using combined HDX-MS and molecular dynamics simulations, validated by experimental data.

Augmenting Neutralization breadth against Diverse HIV-1 by increasing the Ab-Ag interface on V2

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

Structural insights into GlcNAc-1-phosphotransferase that directs lysosomal protein transport

The paper presents the cryo-EM structure of Drosophila GNPTAB, revealing its catalytic domain and functional residues, and shows dimer interface importance for human GNPTAB activity.

Phase separation of Mer2 organizes the meiotic loop-axis structure of chromatin during meiosis I

This study shows Mer2 phase separation forms droplet-loop chromatin structures to enable diverse meiotic DSB formation.

Cross-Protection Against Zika Virus Infection Conferred by a Live Attenuated Japanese Encephalitis SA14-14-2 Vaccine

This study shows that the JE vaccine SA14-14-2 protects mice against ZIKV through cross-reactive T cell immunity rather than antibodies.

Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin

This study reports cryo-EM structures of SIgA complexes, revealing their assembly mechanism and interaction with SpsA, a pneumococcal adhesin.

The inverse relationship between fibronectin and neuroligins in the embryonic rat colon

The paper investigates the inverse relationship between fibronectin and neuroligins in the embryonic rat colon, showing direct regulation and negative correlation.

Experimental infection characteristics of Bordetella pertussis via aerosol challenge on rhesus macaques

This study evaluates aerosol challenge of rhesus macaques with B. pertussis, showing similar infection characteristics to humans and supporting their use as a pertussis model.