The NLRP3 inflammasome selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates bacterial killing in vivo
M. Minns, T. Lima, K. Liboro, S. Abbondante, B. A. Miller, M. Marshall, J. Tran-Chau, A. Rietsch, G. Dubyak, E. Pearlman
This study shows that Pseudomonas aeruginosa uses ExoS to redirect neutrophil inflammasome signaling from NLRC4 to NLRP3, enhancing bacterial killing and reducing disease severity in mice.
bioRxiv · Apr 7, 2022 · PreprintMicrobiology