Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts
A. K. Francois, A. Rohani, M. S. Loftus, S. A. Dochnal, J. Hrit, S. McFarlane, A. L. Whitford, A. Lewis, P. A. Krakowiak, C. Boutell, S. B. Rothbart, D. Kashatus, A. R. Cliffe
This study investigates the association of HSV-1 genomes with H3K27me2 and PHF20L1 in fibroblasts, finding that H3K27me2 is linked to genome silencing and that this association is influenced by demethylase activity and transcriptional state.
bioRxiv · Dec 3, 2023Microbiology