Author

S. McFarlane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Boutell· 4 shared I. Epifano· 2 shared J. K. Wojtus· 2 shared K. Dee· 2 shared Q. Gu· 2 shared A. D. S. Filipe· 1 shared A. Ho· 1 shared A. K. Francois· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

C. Boutell

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Interplay of Light, Melatonin, and Circadian Genes in Skin Pigmentation Regulation

G. E. Bertolesi, N. Debnath, N. Heshami, R. Bui, H. Zadeh-Haghighi, C. Simon, S. McFarlane

This study shows that melatonin, not light, primarily drives circadian regulation of melanin synthesis and melanophore proliferation in Xenopus laevis, with melatonin mimicking dark-phase gene expression.

bioRxiv · Jul 22, 2024Physiology

Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts

A. K. Francois, A. Rohani, M. S. Loftus, S. A. Dochnal, J. Hrit, S. McFarlane, A. L. Whitford, A. Lewis, P. A. Krakowiak, C. Boutell, S. B. Rothbart, D. Kashatus, A. R. Cliffe

This study investigates the association of HSV-1 genomes with H3K27me2 and PHF20L1 in fibroblasts, finding that H3K27me2 is linked to genome silencing and that this association is influenced by demethylase activity and transcriptional state.

bioRxiv · Dec 3, 2023Microbiology

Temperature elevation synergises with and enhances the type-I IFN-mediated restriction of MPXV

C. Davis, I. Epifano, K. Dee, S. McFarlane, J. K. Wojtus, B. Brennan, Q. Gu, S. B. Vattipally, L. Tong, L. Orr, A. D. S. Filipe, D. A. Barr, A. Ho, E. C. Thomson, C. Boutell

This study shows that fever enhances the host's type-I IFN response to restrict MPXV replication.

bioRxiv · Sep 29, 2023 · PreprintMicrobiology

Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of the induction of IFN-mediated innate immune defences

V. Herder, K. Dee, J. Wojtus, D. Goldfarb, C. Rozario, Q. Gu, R. Jarrett, I. Epifano, A. Stevenson, S. McFarlane, M. Stewart, A. Szemiel, R. Pinto, A. Masdefiol Garriga, S. Graham, , C. Boutell

This study shows that elevated temperatures inhibit SARS-CoV-2 replication in respiratory epithelium without triggering IFN-mediated immune responses.

bioRxiv · Dec 4, 2020 · PreprintMicrobiology

Constitutive TRIM22 expression within the respiratory tract identifies tissue-specific and cell-type dependent intrinsic immune barriers to influenza A virus infection

M. Charman, S. McFarlane, J. K. Wojtus, E. Sloan, R. Dewar, G. Leeming, M. Al-Saadi, L. Hunter, M. Carroll, J. P. Stewart, P. Digard, E. Hutchinson, C. Boutell

This study identifies TRIM22 as a constitutively expressed antiviral factor in the respiratory tract that restricts influenza A virus infection independently of cytokine-mediated immunity.

bioRxiv · Jun 21, 2019 · PreprintImmunology