Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer
D. De Felice, A. Alaimo, D. Bressan, S. Genovesi, E. Marmocchi, N. Annesi, G. Beccaceci, D. Dalfovo, F. Cutrupi, V. Foletto, M. Lorenzoni, F. Gandolfi, S. Kannan, C. S. Verma, A. Vasciaveo, , A. Lunardi
This study shows RA signaling promotes luminal identity in prostate progenitors through Foxa1, and identifies a loss-of-function mutation in Foxa1 linked to prostate cancer dedifferentiation.
bioRxiv · Mar 6, 2024Cancer Biology