C. S. Verma

This paper develops a coarse-grained model for glycosaminoglycans compatible with Martini forcefields, enabling simulation of their conformational and thermodynamic properties.

This study develops macrocyclic peptides that inhibit the Skp2-p27 interaction by binding to SCFSkp2/Cks1, reducing cell proliferation in breast cancer cells.

The paper develops design rules for stapled alpha-helical peptides to improve in vivo activity and reduce off-target effects, demonstrating significant improvements in potency and safety.

The paper designs and tests stapled peptides that inhibit DAXX, a protein involved in cancer, showing they enter cells and disrupt its interactions with other proteins.

This paper develops a novel peptide aptamer that binds eIF4E's cap-binding site using PELE, showing nanomolar affinity and intracellular function modulation.

This study evaluates the synergistic interaction of CaD23 with antibiotics and identifies its membrane-permeabilizing mechanism through experimental and molecular dynamics simulations.

This study identifies TRAF4 as a tumor suppressor in bladder cancer that promotes BMP/SMAD signaling and inhibits metastasis by targeting SMURF1 for degradation.

The paper develops bioactive peptides that modulate eIF4E binding by inducing conformational order in intrinsically disordered regions of eIF4G.

This study identifies how Src kinase promotes retrograde membrane traffic by phosphorylating GBF1, facilitating its interaction with Arf1 and enabling GALNTs relocation from Golgi to ER.

This paper extends the Martini forcefield to model N-glycans by optimizing coarse-grained parameters and validating them against experimental data on lectin binding and solvation properties.

This study identifies YB-1's role in cytokinesis by showing its necessity for microtubule organization and phosphorylation-dependent function.

The paper determines the 3D structure of a chitin-binding domain from a squid CBP using NMR, revealing how the R&R motif binds chitin and providing insights for biomimetic material design.

This paper combines macrocyclization and D-amino acid strategies to create an all-D helical peptide with improved target affinity and cellular activity.

This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.