Ezh2 restrains macrophage inflammatory responses, and is critical for neutrophil migration in response to pulmonary infection.
G. B. Kitchen, T. Hopwood, T. G. Ramamoorthy, P. Downton, N. Begley, T. Hussell, D. H. Dockrell, J. E. Gibbs, D. W. Ray, A. S. Loudon
This study shows EZH2 has divergent roles in macrophages and neutrophils, enhancing macrophage immunity but impairing neutrophil chemotaxis during pulmonary infection.
bioRxiv · Jul 24, 2020 · PreprintCell Biology