Author

D. A. Bechtold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. W. Ray· 3 shared J. E. Gibbs· 2 shared P. Downton· 2 shared P. S. Cunningham· 2 shared A. Adamson· 1 shared A. J. Fisher· 1 shared A. L. Hunter· 1 shared A. Nazgiewicz· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

D. W. Ray

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3 papers

Recent·Most cited

Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis

P. Downton, S. H. Dickson, D. W. Ray, D. A. Bechtold, J. E. Gibbs

This study shows that fibroblast-like synoviocytes' circadian clock influences daily inflammation rhythms in arthritis, with Bmal1 deletion reducing arthritis susceptibility but increasing MMP3 production.

bioRxiv · Apr 2, 2024Immunology

Adipocyte REVERBα dictates adipose tissue expansion during obesity

A. L. Hunter, C. E. Pelekanou, N. J. Barron, R. C. Northeast, A. Adamson, P. Downton, T. Cornfield, P. S. Cunningham, L. Hodson, A. S. I. Loudon, R. D. Unwin, M. Iqbal, D. W. Ray, D. A. Bechtold

This study shows adipocyte REVERBα regulates metabolic processes in white adipose tissue during obesity, preventing inflammation and fibrosis without affecting daily lipogenesis rhythms.

bioRxiv · Sep 23, 2020Physiology

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

P. S. Cunningham, P. Meijer, A. Nazgiewicz, S. G. Anderson, L. A. Borthwick, J. Bagnall, G. B. Kitchen, M. Lodyga, N. Begley, R. V. Venkateswaran, R. Shah, P. F. Mercer, H. J. Durrington, N. C. Henderson, K. Piper-Hanley, , J. Blaikley

This study identifies REVERBα as a regulator of pulmonary fibrosis by modulating circadian rhythms and integrin β1 focal adhesion formation in fibroblasts, with potential therapeutic implications.

bioRxiv · Sep 25, 2019Cell Biology