Author

P. Downton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. W. Ray· 3 shared D. A. Bechtold· 2 shared J. E. Gibbs· 2 shared A. Adamson· 1 shared A. D. Adamson· 1 shared A. L. Hunter· 1 shared A. S. I. Loudon· 1 shared A. S. Loudon· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

D. W. Ray

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis

P. Downton, S. H. Dickson, D. W. Ray, D. A. Bechtold, J. E. Gibbs

This study shows that fibroblast-like synoviocytes' circadian clock influences daily inflammation rhythms in arthritis, with Bmal1 deletion reducing arthritis susceptibility but increasing MMP3 production.

bioRxiv · Apr 2, 2024Immunology

Overexpression of IkappaBalpha modulates NF-kappaB activation of inflammatory target gene expression

P. Downton, J. S. Bagnall, H. England, D. G. Spiller, N. Humphreys, D. A. Jackson, P. Paszek, M. R. H. White, A. D. Adamson

This study shows that overexpression of IκBα reduces inflammatory gene expression by inhibiting p65 promoter binding, even when p65 dynamics remain intact.

bioRxiv · Mar 14, 2023Cell Biology

Adipocyte REVERBα dictates adipose tissue expansion during obesity

A. L. Hunter, C. E. Pelekanou, N. J. Barron, R. C. Northeast, A. Adamson, P. Downton, T. Cornfield, P. S. Cunningham, L. Hodson, A. S. I. Loudon, R. D. Unwin, M. Iqbal, D. W. Ray, D. A. Bechtold

This study shows adipocyte REVERBα regulates metabolic processes in white adipose tissue during obesity, preventing inflammation and fibrosis without affecting daily lipogenesis rhythms.

bioRxiv · Sep 23, 2020Physiology

Ezh2 restrains macrophage inflammatory responses, and is critical for neutrophil migration in response to pulmonary infection.

G. B. Kitchen, T. Hopwood, T. G. Ramamoorthy, P. Downton, N. Begley, T. Hussell, D. H. Dockrell, J. E. Gibbs, D. W. Ray, A. S. Loudon

This study shows EZH2 has divergent roles in macrophages and neutrophils, enhancing macrophage immunity but impairing neutrophil chemotaxis during pulmonary infection.

bioRxiv · Jul 24, 2020 · PreprintCell Biology