Pharmacology & ToxicologybioRxiv
Discovery and characterization of a chemical probe targeting the zinc-finger ubiquitin-binding domain of HDAC6
R. J. Harding, I. Franzoni, M. K. Mann…·C. H. Arrowsmith
The paper identifies and characterizes a chemical probe, SGC-UBD253, that targets the HDAC6 UBD with selectivity, and a less active derivative as a negative control.
DOI 10.1021/acs.jmedchem.3c00314